Strontium ranelate dry suspension

A technology of strontium ranelate and dry suspension, applied in bone diseases, powder delivery, drug combination, etc.

Inactive Publication Date: 2010-09-29
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be taken without boiling water, but it is not suitable for many elderly patients who cannot chew

Method used

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  • Strontium ranelate dry suspension
  • Strontium ranelate dry suspension
  • Strontium ranelate dry suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prescription composition:

[0021]

[0022] Preparation technology: take by weighing the raw and auxiliary materials of the recipe quantity, pass through a 100-mesh sieve, and make starch into 15% starch slurry for subsequent use; first mix strontium ranelate and mannitol to obtain mixture I; then mix mixture I with xanthan gum, Sodium carboxymethyl starch is mixed uniformly according to the equal amount incremental method, and an appropriate amount of 15% starch slurry is added to make granules, dried at 50°C, granulated, and graded to obtain Granule I, which is mixed with tartrazine, aspartame, and orange essence. The mixture II is uniformly obtained, and the mixture II is divided into a dry suspension to obtain a dry suspension.

[0023] Dry Suspension Check

[0024] 1. Check the sedimentation volume ratio: according to the appendix IO method of "Chinese Pharmacopoeia 2005 Edition".

[0025] After dispersing the two bags of particles in 200 ml of cold water and ...

Embodiment 2

[0038]

[0039]

[0040] Preparation technology: take by weighing the raw and auxiliary materials of the recipe quantity, pass through a 100-mesh sieve, and make maltodextrin into 20% maltodextrin pulp for subsequent use; first mix strontium ranelate and mannitol evenly to obtain mixture I; then mix mixture I with Sodium alginate was mixed uniformly by the equal amount incremental method, and an appropriate amount of 20% maltodextrin pulp was added to granulate, dried at 50°C, granulated, and classified to obtain Granule I, which was mixed with fruit green, sucralose and green apple essence. The mixture II is uniformly obtained, and the mixture II is divided into a dry suspension to obtain a dry suspension.

[0041] Dry Suspension Check

[0042] 1. Check the sedimentation volume ratio: according to the appendix IO method of "Chinese Pharmacopoeia 2005 Edition".

[0043] After dispersing the two bags of particles in 200 ml of cold water and 200 ml of hot water, respectiv...

Embodiment 3

[0055] Prescription composition:

[0056]

[0057] Preparation technology: take by weighing the raw and auxiliary materials of the recipe quantity, pass through a 100-mesh sieve, and make starch into 15% starch slurry for subsequent use; first mix strontium ranelate and xylitol homogeneously to obtain mixture I; then mix mixture I with xanthan gum , Sodium carboxymethyl starch is mixed uniformly according to the equal amount incremental method, and an appropriate amount of 15% starch slurry is added to granulate, dried at 50 ° C, granulated, and graded to obtain granules I, and granules I are mixed with tartrazine, aspartame, and orange essence. Mix well to obtain mixture II, and divide the mixture II to obtain a dry suspension.

[0058] Dry Suspension Check

[0059] 1. Check the sedimentation volume ratio: according to the appendix IO method of "Chinese Pharmacopoeia 2005 Edition".

[0060] After dispersing the two bags of particles in 200 ml of cold water and 200 ml of ...

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Abstract

The invention discloses a dry suspension containing strontium ranelate. The dry suspension contains the following components by weight ratio: 50-90 per cent of lactose, or xylitol, or mannite or 50-90 per cent of the combination of lactose, xylitol, mannite; 10-49 per cent of strontium ranelate; 0.1-10 per cent of correctives; 0.1-10 per cent of colorant; and 1-20 per cent of adhesive. With good stability, the dry suspension containing strontium ranelate disclosed in the invention is used for curing and preventing the menopausal osteoporosis.

Description

technical field [0001] The invention relates to a dry suspension, in particular to an oral dry suspension containing strontium ranelate. Background technique [0002] Strontium ranelate, the chemical name is 3-thiopheneacetic acid-5-[di(carboxymethyl)amino]-2-carboxy-4-cyano, strontium salt (1:2). The structural formula is as follows: [0003] [0004] Molecular formula: C12H6N208SSr2 Molecular weight: 513.49 [0005] The strontium ranelate involved in the present invention is developed by Servier of France, approved in the European Union in September 2004, and listed in Ireland and the United Kingdom. The trade name is Protelos, and the dosage form is granules. Prevention of osteoporosis in postmenopausal women. [0006] Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, accompanied by symptoms such as increased bone fragility, susceptibility to fractures, and pain. [0007] Strontium ranel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/381A61P19/10
Inventor 陈芳
Owner BEIJING D VENTUREPHARM TECH DEV
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