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Preparation method and composition and Chinese traditional medicine preparation for preventing and curing hyperuricaemia

A technology for hyperuricemia and traditional Chinese medicine preparations, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as shortages, and achieve the effect of reducing blood uric acid.

Inactive Publication Date: 2008-06-25
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Aiming at the lack of traditional Chinese medicines and compositions thereof for treating and preventing hyperuricemia, the present invention provides a drug capable of preventing and treating hyperuricemia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1; Chinese medicine preparation and preparation method for preventing and treating hyperuricemia

[0048] (1) Prescription:

[0049] 2 parts of Cortex Phellodendri, 2 parts of Atractylodes Atractylodes, 1 part of Smilax, and 1 part of Honeysuckle.

[0050] (2) Preparation method:

[0051] Take 2.0 parts of Atractylodes atractylodes, 2.0 parts of Phellodendron Phellodendron, 1.0 part of Smilax cocos, and 1.0 part of Lonicerae vine and extract with 95% ethanol, and recover the ethanol from the extract to obtain a concentrated solution, which is concentrated to 3g of crude drug / ml, which can treat and prevent hyperuricemia. Chinese medicine preparations.

Embodiment 2

[0052] Embodiment 2: Chinese medicinal composition for preventing and treating hyperuricemia and preparation method thereof:

[0053] (1) Prescription:

[0054] 2 parts of Phellodendron alkaloids, 2 parts of Atractylodes volatile oil, 1 part of Smilax cocos, 1 part of honeysuckle organic acid, 1 part each of Smilax cocos, honeysuckle saponins, and flavonoids.

[0055] (2) Preparation method:

[0056] (1) Extraction of Cortex Phellodendri Alkaloid I:

[0057] Take 2 parts of Cortex Phellodendri with 6-8 times the amount of 60% ethanol to extract 4 times, recover the ethanol from the extract, let it stand and centrifuge, discard the precipitate to get the supernatant, put it on a macroporous resin column, wash with water until colorless, and elute with 50% ethanol , collect eluate, reclaim ethanol, obtain alkaloid extract (I), alkaloid purity 50%, stand-by;

[0058] (2) Extraction of Atractylodes volatile oil II:

[0059] Take 2 parts of Atractylodes atractylodes and extract...

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Abstract

The invention relates to a traditional Chinese medicinal preparation used for preventing and treating hyperuricemia and a combination thereof, which are respectively formulated by amur corktree, Chinese actractylodes, glabrous greenbrier rhizome and honeysuckle stem by weight proportion, or formulated by certain weight of extract alkaloids, ligroine, saponin and flavone thereof.Wherein, the method of the medicinal preparation is that: after the Chinese actractylodes, the amour corktree, the glabrous greenbrier rhizome and the honeysuckle stem are mixed, ethanol is used for extracting thereof; concentration solution is obtained by recycling the ethanol; then the medicinal preparation is made.The alkaloids is extracted from the Chinese atractylodes by steam distillation; extractable fluid and dregs are obtained from the glabrous greenbrier rhizome and honeysuckle stem by using acetone; extract is obtained by recycling the acetone in the extractable liquid; after the extract is dissolved by alkali, organic acid is prepared by replacing anionic with resin to be depurated; the saponin and the flavone are obtained by using alcohol extract and n-butanol extract to purify the dregs; at last, the medicine is prepared by certain proportion. The medicine provided by the invention has significant hypouricemic activity.

Description

[0001] Technical field: the present invention relates to the field of traditional Chinese medicine, in particular to a Chinese medicinal preparation and composition for the prevention and treatment of hyperuricemia made from Chinese herbal medicines as raw materials and active ingredients extracted from the raw materials and its preparation method. Background technique [0002] Hyperuricemia is a disorder of purine metabolism. Asymptomatic hyperuricemia is a pre-stage state of gout. Untreated hyperuricemia may lead to uric acid nephropathy or uric acid nephrolithiasis, and is associated with hypertension, hyperlipidemia, coronary heart disease, stroke, diabetes occurrence are closely related. Hyperuricemia is a major risk factor for gout, urinary tract stone disease, and acute uric acid nephropathy. At present, the incidence of gout is increasing day by day, and the number of patients dying of hyperuricemia, renal damage and renal failure has increased significantly, and it h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P7/00A61P19/06
Inventor 尹莲徐立时乐
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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