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Compound pharmaceutical composition, preparation method and use of the same

A composition and drug technology, applied in the field of antipyretic, analgesic, and anti-inflammatory drugs for livestock and poultry, can solve the problems of short action time, slow action, and easy rebound of antipyretic effect.

Active Publication Date: 2008-07-16
BEIJING DABEINONG ANIMAL HEALTH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing antipyretic drugs have slow action and short action time, and the antipyretic effect is easy to rebound, which cannot meet the clinical needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] prescription:

[0022] Diclofenac Sodium 2g

[0023] Naproxen 4g

[0024] N-methyl-2-pyrrolidone 70ml

[0025] Antioxidant amount

[0026] Add water for injection to 100ml

[0027] Preparation:

[0028] 1. Take the prescribed amount of N-methyl-2-pyrrolidone, add diclofenac sodium, stir to dissolve; add naproxen, stir to dissolve.

[0029] 2. Take an appropriate amount of water for injection, add antioxidant, stir to dissolve.

[0030] 3. Combine 1 and 2, adjust the pH value to 5-8, dilute to 100ml with water for injection, and filter through a membrane.

[0031] 4. Potting, steam sterilization at 100°C for 30 minutes, ready to serve.

Embodiment 2

[0033] prescription:

[0034] Diclofenac Sodium 1g

[0035] Naproxen 5g

[0036] N-methyl-2-pyrrolidone 30ml

[0037] Glycerin Formal 30ml

[0038] Antioxidant amount

[0039] Add water for injection to 100ml

[0040] Preparation:

[0041] 1. Take the prescribed amount of N-methyl-2-pyrrolidone and glycerin formal, mix well; add diclofenac sodium, stir to dissolve; add naproxen, stir to dissolve.

[0042] 2. Take an appropriate amount of water for injection, add antioxidant, stir to dissolve.

[0043] 3. Combine 1 and 2, adjust the pH value to 5-8, dilute to 100ml with water for injection, and filter through a membrane.

[0044] 4. Potting, steam sterilization at 100°C for 30 minutes, ready to serve.

Embodiment 3

[0046] prescription:

[0047] Diclofenac Sodium 4g

[0048] Naproxen 0.5g

[0049] N-methyl-2-pyrrolidone 30ml

[0050] Ethanol 20ml

[0051] Antioxidant amount

[0052] Add water for injection to 100ml

[0053] Preparation:

[0054] 1. Take the prescribed amount of N-methyl-2-pyrrolidone and ethanol, mix well; add diclofenac sodium, stir to dissolve; add naproxen, stir to dissolve.

[0055] 2. Take an appropriate amount of water for injection, add antioxidant, stir to dissolve.

[0056] 3. Combine 1 and 2, adjust the pH value to 5-8, dilute to 100ml with water for injection, and filter through a membrane.

[0057] 4. Potting, steam sterilization at 100°C for 30 minutes, ready to serve.

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PUM

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Abstract

The invention relates to a medical composition used for the febrifuge, analgesia and anti-inflammation of the animals, a preparation method and the application thereof. The medical composition comprises diclophenac sodium and naproxen. The weight proportion of the diclophenac sodium and the naproxen is 1:10-10:1 while the preferred scope is 1:5-5:1. The invention also provides the preparation method of the injection of the medical composition and the application in the control of livestock and poultry pyrexia. The invention has more thorough febrifuge effect than any single preparation with the characteristics of fast action and uneasy rebound relative to the oral preparation.

Description

technical field [0001] The invention belongs to antipyretic, analgesic and anti-inflammatory drugs for livestock and poultry, in particular to a compound pharmaceutical composition containing diclofenac sodium and naproxen and a preparation method thereof. Background technique [0002] When livestock and poultry are attacked by bacteria, viruses, and mycoplasma, most of the clinical symptoms are accompanied by inflammatory symptoms (fever, pain), which affect the normal diet, activities and healthy growth of the demand. Therefore, whether it is from the perspective of animal welfare or animal production, anti-inflammatory (antipyretic, analgesic) is necessary while administering antibacterial and antiviral drugs. [0003] In my country, the prevention and control of livestock and poultry diseases is an important guarantee for the healthy development of animal husbandry. my country has a vast territory, different climates and production habits in different regions, and there...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/196A61P29/00A61K31/192
CPCY02A40/70
Inventor 田玲莫云刘彤郭致君王海良布仁阿古达木
Owner BEIJING DABEINONG ANIMAL HEALTH TECH
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