Compositions and methods for modulating cells via CD14 and toII-like receptor 4 signaling pathway

A signal transduction and receptor technology, applied in the direction of antibodies, biological testing, pharmaceutical formulations, etc., can solve the problem of not having, no host to distinguish between smooth and rough LPS chemotypes
CN101227922AInactive Publication Date: 2008-07-23THE SCRIPPS RES INST
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
THE SCRIPPS RES INST
Publication Date
2008-07-23
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

Compositions and methods for screening and identifying compounds that modulate Toll-like receptor 4 (TLR4) pathway signaling via CD14 and ligands are provided. Provided are methods of treating various disease states, such as inflammatory or autoimmune diseases, in mammalian subjects by modulating Toll-like receptor 4 (TLR4) pathway signaling through CD14 and ligands. Transgenic non-human animals and methods of developing transgenic non-human animals are provided, wherein the transgenic non-human animals contain a loss-of-function mutation in the CD14 gene.
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Description

[0001] Statement of Government Funding

[0002] This invention was made with government support under Grant No. U54-AI54523 from the National Institutes of Health. The government has certain rights in this invention.

[0003] Cross References to Related Applications

[0004] This application claims U.S. Provisional Application No. 60 / 678,393, filed May 6, 2005, and U.S. Provisional Application No. 60 / 678,393, filed May 4, 2006, via Express Mail No. EV800285450US, entitled "Combined Modulation of Cells Via CD14 and Toll-like Receptor 4 Signaling Pathways" COMPOSITIONSAND METHODS FOR MODULATING CELLS VIA CD14 AND TOLL-LIKERECEPTOR 4 SIGNALING PATHWAY", both of which are incorporated herein by reference. technical field

[0005] The present invention relates generally to molecular immunology and treatment of human disease. The present invention relates to methods for screening and identifying compounds based on properties of the Toll-like receptor 4 (TLR4) pathway that signals...

Claims

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