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Simethicone emulsion and preparing method thereof

A technology of simethicone emulsion and simethicone, which is applied in the direction of pharmaceutical formulations, emulsion delivery, medical preparations of non-active ingredients, etc., can solve the problem of limiting flatulence relief, not suitable for diabetics, and inconvenient gastrointestinal tiny bubbles Exhaust and other problems, to achieve the effect of improving clinical curative effect and excellent exhaust effect

Active Publication Date: 2008-07-30
德国柏林化学股份有限公司
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  • Application Information

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Problems solved by technology

[0003] Existing simethicone is often prepared into solid oral preparations, which is inconvenient for infants and young children. In addition, in the past, simethicone is generally about 1000 micron particles, which is not convenient for the discharge of tiny bubbles in the gastrointestinal tract, which limits the relief of flatulence
U.S. Patent 4906478 discloses an activated formulation containing a mixture of water-soluble gelled maltodextrin and activated simethicone, but is not suitable for diabetics

Method used

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  • Simethicone emulsion and preparing method thereof
  • Simethicone emulsion and preparing method thereof
  • Simethicone emulsion and preparing method thereof

Examples

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Effect test

example 1

[0078] Simethicone and silicon dioxide have only a very weak defoaming effect when used alone, but when the two are mixed, the mixture has a significant defoaming effect. Animal experiments have shown that to eliminate the same foam in the stomach of rats, 750mg of simethicone, 80mg of silicon dioxide, and 5mg of simethicone are needed (R.D.N. BIRTLEY THE EFFECT OF FREE SILICA ON THE MUCOSAL PROTECTIVE AND ANTIFLATULENT PROPERTIES).

example 2

[0080] The "Journal of Hepatology and Gastroenterology" published in 2006 compared the evaluation of the defoaming effect of simethicone and simethicone in more than 400 patients. The effective rate of simethicone is 95%, and that of simethicone group is only 35%. Wu Yunlin, "Journal of Hepatology and Gastroenterology", Volume 5, Issue 3, June 2006.

example 3

[0082] Simethicone has also been proven not only to have a definite curative effect on gastrointestinal flatulence, but also to effectively treat functional dyspepsia. Functional dyspepsia accounts for 50% of gastroenterology patients, and simethicone is considered to have a definite curative effect and is used as a prokinetic agent (G.HOLTMANN.AlimentPharmacol Ther 2002; 1641-1648).

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Abstract

The invention relates to an air exhaust agent for stomach and intestine, a simethicone emulsion. The emulsion comprises simethicone latex as the active component and a pharmaceutically permissible carrier or excipient as the non-active component, wherein emulsion content of simethicone is of 25 to 35 percent (or weight percentage) of the total content of the simethicone emulsion and the non-active component of 65 to 75 percent (or weight percentage). The particle size of the simethicone emulsion is 10 to 50nm. The simethicone emulsion of the invention has excellent exhausting effect, which is 150 times more than that of dimethicone; the invention can be applied into any group of people with intestinal inflation symptoms including babies, pregnant women and patients with diabetes, with safety and high efficiency.

Description

technical field [0001] The invention relates to a gastrointestinal exhaust agent-simethicone emulsion, in particular to a nanoscale simethicone emulsion and a preparation method thereof. Background technique [0002] Simethicone is known as a mixture of simethicone (or dimethylpolysiloxane) and silicon dioxide and is commonly used to relieve flatulence or similar unpleasant symptoms. [0003] Existing simethicone is often prepared as a solid oral preparation, which is not convenient for infants and young children. In addition, in the past, simethicone is generally about 1000 micron particles, which is not convenient for the discharge of microscopic air bubbles in the gastrointestinal tract, which limits the relief of flatulence. US Patent 4906478 discloses an activated formulation containing a mixture of water-soluble gelled maltodextrin and activated simethicone, but is not suitable for diabetics. Therefore, need a kind of Simethicone preparation that is safer and more eff...

Claims

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Application Information

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IPC IPC(8): A61K31/80A61K9/107A61K47/38A61P1/00
Inventor 卢盖·特班提
Owner 德国柏林化学股份有限公司
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