Chip and method for testing biological corpuscle dielectric property

Abstract

The invention relates to a biological particulate dielectric property test chip and a test method, which can realize multimodal test and manipulation for the dielectric property of active biological particulates so as to solve the defects existing in the prior art that the dielectric property information of the biological particulates is obtained insufficiently, the veracity is low and the samplepretreatment cannot be accomplished on the test chip. The method has the steps that: various dielectrophoresis modes in alternating current electric field such as the normal dielectrophoresis, the traveling wave dielectrophoresis and the electric rotation dielectrophoresis, etc. and the combination of the modes are used to carry out the test for the dielectric property of the biological particulates. The biological particulates are induced to generate various dielectrophoresis behaviors through changing the frequency and the amplitude of a sinusoidal actuating signal, furthermore, the dielectric parameter of the particulates is reversely obtained through synthetically considering the suspending height, the horizontal radial speed as well as the electric rotational angular velocity and so on. Simultaneously, by utilizing the dielectric behaviors, the biological particulates are manipulated through adjusting the frequency and the amplitude of the actuating signal to accomplish the pretreatment of the sample dispensing with an external micro-pump, a micro-valve and a filter, thereby avoiding the hidden trouble that the micro-pump or the micro-valve is blocked by weeny substance.

Description

technical field The invention relates to a device and method for testing the dielectric properties of micro-nano biological particles and a manipulation technology for micro-nano particles. Background technique In biochemical analysis, it is often necessary to detect and analyze the characteristics of biological particles, and then explore their internal structure and chemical composition to meet the needs of medical research, health and epidemic prevention, etc. Traditional biochemical analysis methods usually add biochemical reagents to react with biological particles, and strictly control the reaction process, which not only destroys the microenvironment of biological particles, is not suitable for the analysis of active biological particles, but also the related equipment is bulky and expensive , has high requirements on the test environment and personnel, especially in disease detection, and is not suitable for personalization and home use. In addition, in the biochemi...

AI Technical Summary

Problems solved by technology

Technical problem: the object of the present invention is to provide a kind of biological particle dielectric characteristic test chip and testing method, can realize the multi-mode test and manipulation to the dielectric characteristic of active biological particle to solve the problem of biological particle (especially Insufficient acquisition of information on dielectric properties, low accuracy, and inability to complete sample pretreatment on the test chip

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