Method for preparing embolism-extinguishing enteric-coated capsule
An enteric-coated capsule and uniform mixing technology, which is applied in the field of medicine, can solve the problems of inactive lumbrokinase, incomplete extraction of active components, and influence on the effect of drug treatment, and achieves the effect of complete extraction and improved treatment effect.
Active Publication Date: 2011-04-13
三门峡赛诺维制药有限公司
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Problems solved by technology
The drug extracts in Xiaoshuan Oral Liquid and Xiaoshuan Granules are extracted by using the traditional water decoction method, and the active ingredients are not extracted completely. At the same time, the protein extracted by the method of water decoction has been denatured, and its lumbrokinase No biological activity, affecting the therapeutic effect of the drug
Method used
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Embodiment Construction
[0006] Take the preparation of 100 kg Xiaoshuan enteric-coated capsules as an example.
[0007] Example 1. After mixing 420 kg of Chinese medicine Astragalus membranaceus, 48 kg of Angelica sinensis, and 20 kg of Rhizoma Chuanxiong evenly, add three times the amount of 70% ethanol, soak for 1 hour, heat and reflux twice, each time for 2 hours, filter respectively, and combine the filtrates. First, the filtrate is concentrated under reduced pressure at a temperature of 50°C until the relative density is 1.2g / ml for later use, and then the filtered medicinal residue is decocted with 42 kg of Chinese herbal medicine Radix Paeoniae Rubra, 24 kg of peach kernels, and 24 kg of safflower three times. After 2 hours, filter respectively, combine the filtrate, concentrate the filtrate under reduced pressure to a relative density of 1.1g / ml, then add 4 times the amount of 95% ethanol to the concentrated solution, stir, let stand, and after releasing the supernatant, reduce Concentrate ...
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The invention discloses the preparation method of a medicine anti-plug enteric soluble capsule for curing anemic apoplexy, deficiency of vital energy and blood stasis. The Chinese medicines astragalus root, angelica and rhizoma ligustici wallichii are steeped into ethanol, the ethanol return flows twice, then is filtered; the filtrate is condensed at certain temperature; the dregs of a decoction are decocted in water with Chinese medicine rot of peony, semen persicae and safflower, then the liquid is filtered; the filtrate is condensed, and the concentrated solution is added by ethanol, stirred and standing; a supernatant fluid is given out and is carried on decompression condensation. Two condensates above are mixed and dried, then grinded so that an extractive is obtained; a fresh lumbricus is dried in shade and grinded, then steeped into water, an extract solution is obtained, decentered, condensed, a condensate is obtained, dried in vacuum at a certain temperature then grinded so that a lumbricus extract is obtained; the extract above is mixed with the lumbricus extract, then packed into the enteric soluble capsule. The effective ingredient of the Chinese medicine of the invention is extracted entirely, and the biological activity of the lumbrokinase of the lumbricus is kept so that the curing effect of the medicine is improved.
Description
technical field [0001] The invention relates to a preparation method of a medicine for treating ischemic stroke due to qi deficiency and blood stasis, in particular to a preparation method of Xiaoshuan enteric-coated capsules, which belongs to the technical field of medicine. Background technique [0002] At present, there are many drugs for the treatment of ischemic stroke due to qi deficiency and blood stasis, and the commonly used dosage forms are Xiaoshuan Oral Liquid and Xiaoshuan Granules. The production method of Xiaoshuan Oral Liquid is generally to decoct the traditional Chinese medicine astragalus, angelica, chuanxiong, red peony root, peach kernel, safflower, and earthworm for three times, combine the decoction liquid, filter, and add ethanol after the filtrate is concentrated under reduced pressure. Stand still, take the solution, recover ethanol, concentrate the liquid medicine, add water to dilute, add sweetener and preservative, mix well, fill and seal, and st...
Claims
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IPC IPC(8): A61K36/481A61K9/48A61P9/10A61P7/02A61K35/64A61K35/62
Inventor 赵占武刘黎明屈志莲贺航运张少杰刘守志连亚丽关静
Owner 三门峡赛诺维制药有限公司