Method for preparing red sage root salviandic acid A

Abstract

The invention discloses a preparation method for salvianolic acid A in salvia miltiorrhiza and is characterized in that the method takes salvianolic acid B in the salvia miltiorrhiza as the raw material and converts the salvianolic acid B into the salvianolic acid A in the salvia miltiorrhiza after adjusting pH value to 3.5-6.0 and chemical reaction, thus greatly increasing the extraction yield of the salvianolic acid A; the pharmacological tests prove that a preparation prepared by the salvianolic acid A in the salvia miltiorrhiza has excellent pharmacological action.

Description

technical field [0001] The invention relates to the technical field of medicine and health food, in particular to a preparation method of salvianolic acid A, that is, salvianolic acid B is used as a raw material, and the pH is adjusted to 3.5-6.0, and the chemical reaction is converted into salvianolic acid A . [0002] The chemical reaction method in the present application refers to a conventional chemical reaction method in organic chemistry, which does not require the addition of a catalyst, and is carried out by itself under a certain pH value. [0003] The content of salvianolic acid B in this application is 10%-100%, that is, salvianolic acid B can be an extract, an effective part, an effective part of a component, an active ingredient or a pure product; it can also be a crude product with a content of less than 10%. Extract. Background technique [0004] Salvia miltiorrhiza is a classic medicinal flavor of promoting blood circulation and removing blood stasis in tr...

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Problems solved by technology

[0005] The existing documents and patents disclose the extraction and purification process of salvianolic acid A. Although salvianolic acid A can be obtained, the focus is on how to separate salvianolic acid A from impurities. It is very low, it cannot be realized in industrial production, and it is also impossible to obtain "pharmaceutical" grade salvianolic acid A. This is a difficulty facing many scientific researchers.

Chinese patent CN1397276A disclosed in 2002 water or alcohol extraction, resin chromatography, and then purified by silica gel column chromatography to prepare the method for salvianolic acid A; A method for preparing salvianolic acid A through acid adjustment, organic solvent extraction, and reverse phase column chromatography; Chinese patent CN1887849A disclosed in 2006 a method for water or alcohol extraction, column chromatography, pH adjustment, and organic solvent extraction; these methods They all directly extract salvianolic acid A from Danshen and then design a series of purification methods to obtain salvianolic acid A. However, because the content of salvianolic acid A in Danshen is low, the extraction rate of these methods is very low and cannot be realized. Industrialized production, also can't develop the pharmaceutical preparation that is applied to clinical; ℃, the pressure is 0.01-0.25MPa, obviously this cannot be realized in actual operation, because temperature has a certain relationship with pressure, and this application obviously does not conform to this relationship, so the operation cannot be realized

[0006] According to literature and patents, there is no process for obtaining salvianolic acid A through chemical reaction using salvianolic acid B as raw material

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