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Fenticonazole suppository for treating exterior colpitis

A technology for fenticonazole nitrate and vaginitis, applied in the directions of suppository delivery, sexual diseases, drug combination, etc., can solve the problems of short effective administration time, difficult control of drug dose, easy outflow, etc., and achieve long duration of drug effect , good therapeutic effect, good antibacterial effect

Inactive Publication Date: 2008-12-03
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the gel increases the skin permeability of fenticonazole, it is difficult to control the dosage of the drug during use, and it is not as convenient as a suppository
[0004] At present, the common suppository sold on the market will melt in about half an hour, easy to leak out, and the effective administration time is short
At the same time, large doses of administration will cause great irritation

Method used

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  • Fenticonazole suppository for treating exterior colpitis
  • Fenticonazole suppository for treating exterior colpitis
  • Fenticonazole suppository for treating exterior colpitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015]

[0016] Preparation:

[0017] Weigh the prescribed amount of gelatin, add water to swell, put it in a water bath to melt, add glycerin and stir evenly, and remove excess water; weigh the prescribed amount of hydrogenated soybean lecithin, titanium dioxide, sodium ethylparaben and sodium propylparaben and add In the molten base, mix evenly; weigh the prescription amount of fenticonazole nitrate and add it into the molten base, mix evenly; pack in cans, and seal; to obtain.

Embodiment 2

[0019]

[0020]

[0021] Preparation:

[0022] Weigh the gelatin of the prescribed amount, add water to swell, put it in a water bath to melt, add glycerin and stir evenly, and remove excess water; weigh the prescribed amount of hypromellose, titanium dioxide, sodium ethylparaben and propylparaben Sodium is added into the molten matrix and mixed uniformly; the prescribed amount of fenticonazole nitrate is weighed and added into the molten matrix, mixed uniformly; canned and sealed; to obtain.

Embodiment 3

[0024]

[0025] Preparation:

[0026] Weigh the prescribed amount of gelatin, add water to swell, put it in a water bath to melt, add glycerin and stir evenly, and remove excess water; weigh the prescribed amount of polyvinylpyrrolidone, titanium dioxide, sodium ethylparaben and sodium propylparaben and add In the molten base, mix evenly; weigh the prescription amount of fenticonazole nitrate and add it into the molten base, mix evenly; pack in cans, and seal; to obtain.

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PUM

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Abstract

The invention discloses a suppository for treating vulvovaginitis, comprising fenticonazole nitrate, glycerogelatin matrix and additives capable of playing a part in slow release. The suppository can have the effects of inhibiting the rapid rise of the blood drug level and prolonging the acting time.

Description

technical field [0001] The invention relates to a gynecological external suppository for treating vaginitis, in particular to a fenticonazole suppository. Background technique [0002] Fungal vaginitis is one of the three major vaginal common diseases in women (the remaining two are bacterial vaginosis and trichomonal vaginitis), and its incidence rate is high, and it is difficult to cure it. Fenticonazole nitrate is an antifungal drug with short course of treatment, few side effects and good tolerance. [0003] KR930010579B discloses a gel of fenticonazole. Although the gel increases the skin permeability of fenticonazole, it is difficult to control the dosage of the drug during use, and it is not as convenient as a suppository. [0004] At present, the common suppositories sold on the market will all melt in about half an hour, are easy to leak out, and have a short effective administration time. Simultaneously, large dose administration, stimulation is big. Therefore,...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/02A61K47/38A61P15/02
Inventor 袁筝
Owner BEIJING D VENTUREPHARM TECH DEV
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