Integral fluorescence transmission imaging system for beastie

An imaging system and small animal technology, applied in the field of biomedical imaging, can solve problems such as inaccurate tumor location

Inactive Publication Date: 2008-12-10
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

[0003] The purpose of the present invention is to provide a whole-body fluorescence transmission imaging system for small animals, which can solve the problem of inaccurate tumor localization by the existing whole-body fluorescence optical imaging technology

Method used

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  • Integral fluorescence transmission imaging system for beastie
  • Integral fluorescence transmission imaging system for beastie
  • Integral fluorescence transmission imaging system for beastie

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Embodiment Construction

[0016] Below in conjunction with accompanying drawing and example the present invention is described in further detail.

[0017] Such as figure 1 As shown, the overall fluorescent transmission imaging system of the present invention includes an X-ray source 1, a flat panel detector 6, a data acquisition card 9, an object stage 5, a plane mirror 7, a charge coupler 4, an optical filter 8, and a first light emitting diode 2 , the second LED 3, the computer 10.

[0018] The flat-panel detector 6 is at the bottom of the system, and above the flat-panel detector is the stage 5 on which the sample is placed. Above the stage 5 is a flat mirror 7 at an angle α of 45 degrees to the horizontal line. Above the flat mirror is the X-ray source. 1; the center line of the system passes through the ray source 1, the center of the plane mirror, and is also the perpendicular bisector of the flat panel detector 6 and the stage; the first light-emitting diode 2 is placed not far above the two si...

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Abstract

The invention discloses an integral fluorescence transmission imaging system used for small animals; the structure of the imaging system is as follows: a flat panel detector, an object stage, a flat mirror and an X-ray source are sequentially arranged from top to bottom, and the centers thereof are located on the same line; two LBDs, the centers of which are arranged on the same horizontal line, are respectively arranged above both sides of the X-ray source; a filter and a charge-coupled device are positioned on the side of the non-working surface of the flat mirror; the filter and the charge-coupled device share a common axis which goes through the center of the flat mirror; and the flat panel detector and the charge-coupled device are connected with a computer via a data acquisition board. The invention takes the advantage of digital X-ray transmission imaging technology in terms of structural imaging to solve the problem of inaccurate tumor locating of the current integral fluorescent optical imaging technology. The invention adopts computers to fuse the images acquired by the digital X-ray transmission imaging technology and the integral fluorescent optical imaging technology, thereby acquiring more detailed tumor information. Therefore, an effective research tool is provided for researching the invasion, growth and translocation of the tumor.

Description

technical field [0001] The invention belongs to biomedical imaging technology, and in particular relates to an integral fluorescent transmission imaging system for small animals. The system can perform digital X-ray transmission imaging and integral fluorescent optical imaging on small animals at the same time, and is suitable for tumor detection in biomedicine. Research. Background technique [0002] Digital X-ray transmission imaging technology is a relatively mature technology and has been successfully applied clinically. This technology plays an important role in the study of tumor diseases and can provide detailed structural information of small animals. Whole-body fluorescence optical imaging technology has played a great role in the field of detecting and studying tumors. In the Chinese patent document CN1773258 (disclosure date is May 17, 2006), the overall fluorescence optical imaging technology system is used to study tumors in small animals, but the quality of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/00
CPCA61B6/508
Inventor 骆清铭曾绍群毕昆奚磊方正
Owner HUAZHONG UNIV OF SCI & TECH
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