Unlock instant, AI-driven research and patent intelligence for your innovation.

Glycerol fruit sugar injection and preparation method thereof

A technology of injection and glycerin, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, drug delivery, etc. It can solve the problems of water and electrolyte disorder, high concentration of mannitol, rebound intracranial pressure, etc., and achieve the effect of drug solution stability

Active Publication Date: 2011-10-19
AOLING BODA MEDICINE SCI & TECH DEV BEIJING
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. Water and electrolyte disturbance
It solves the problem of crystals easily appearing in single-use mannitol injection, the problem of intracranial pressure rebound caused by high mannitol concentration, the problem of osmotic nephropathy (or mannitol nephropathy), and the short duration of drug effect; Single-use glycerol-fructose composition injection (the formula consists of glycerin, fructose, sodium chloride, and water for injection) or glycerol-sodium chloride injection (the formula consists of glycerin, sodium chloride, and water for injection) has slow onset of dehydration and antihypertensive effects The problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 (specification: 250ml)

[0041] The weight of each composition is as follows in the prescription of preparing 250000ml glycerin fructose composition injection:

[0042] Glycerin 15kg Fructose 6.25kg Mannitol 10kg

[0043] Sorbitol 10kg Glucose 6.25kg Sodium Chloride 2.25kg

[0044] Add water for injection to 250000ml

[0045] The preparation process is as follows:

[0046] Accurately weigh 15kg mannitol and 10kg sorbitol, add 50000ml water for injection, heat the water for injection until the temperature of the water for injection reaches 80°C, heat while stirring to dissolve all mannitol and sorbitol; accurately weigh 6.25kg fructose, 6.25kg Glucose, 2.25kg sodium chloride are added in the above-mentioned solution, stir to make it dissolve completely, heat to boiling, take by weighing 2500g needle-use activated carbon and add in the liquid medicine, stir for 15 minutes and then let stand for 40 minutes, stirring and stand still process Keep the liquid ...

Embodiment 2

[0047] Embodiment 2 (specification: 250ml)

[0048]The weight of each composition is as follows in the prescription of preparing 250000ml glycerin fructose composition injection:

[0049] Glycerin 20kg Fructose 6.25kg Sodium Chloride 2.25kg

[0050] Sorbitol 20kg Glucose 6.25kg

[0051] Add water for injection to 250000ml

[0052] The preparation process is as follows:

[0053] Accurately weigh 20kg of sorbitol, add 50000ml of water for injection, heat the water for injection until the temperature of the water for injection reaches 70°C, heat while stirring to dissolve all the sorbitol; accurately weigh 6.25kg of fructose, 6.25kg of glucose, 2.25kg of sodium chloride Add to the above solution, stir to dissolve completely, heat to boiling, weigh 2000g of activated carbon for needles and add it to the liquid medicine, stir for 10 minutes and then let it stand for 30 minutes. The temperature of the liquid medicine during the stirring and standing process is kept at 85°C After...

Embodiment 3

[0054] Embodiment 3 (specification: 250ml)

[0055] The weight of each composition is as follows in the prescription of preparing 250000ml glycerin fructose composition injection:

[0056] Glycerin 30kg Fructose 6kg Mannitol 10kg

[0057] Sorbitol 5kg Glucose 6kg Sodium Chloride 2.25kg

[0058] Add water for injection to 250000ml

[0059] The preparation process is as follows:

[0060] Accurately weigh 10kg mannitol and 5kg sorbitol, add 100000ml water for injection, heat the water for injection until the temperature of the water for injection reaches 70°C, heat while stirring to dissolve all mannitol and sorbitol; accurately weigh 6kg fructose, 6kg glucose, 2. Add 25kg of sodium chloride into the above solution, stir to dissolve it completely, heat to boiling, weigh 1800g of active carbon for needles and add it to the liquid medicine, stir for 15 minutes and then let it stand for 60 minutes. Keep the temperature at 90°C, and remove the activated carbon after standing for ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a glycerol levulose combination injection liquid and a preparation method thereof, belonging to the technical field of medicine preparation. The invention provides the clinic with a composite dehydrating and depressurizing preparation which takes effective quickly in terms of dehydration and depressurization, achieves long effect maintaining, few side effects, can provide energy support and is stable in terms of medicinal liquid. The prescription of the glycerol levulose combination injection liquid provided by the invention is composed of glycerol, fructose, mannitol, sorbitol, glucose and sodium chloride, injection water. The preparation process is as the following: the mannitol, sorbitol, fructose and glucose are heated and dissolved with the addition of a certain amount of water, undergoes active carbon absorption and decarbonization and is then added with glycerol and a certain amount of injection water; the PH value of the medicinal liquid is adjusted after the treatment of active carbon absorption and is separately placed after a content qualification; the glycerol levulose combination injection liquid is obtained after sterilization of the medicinal liquid. The key of the preparation method lies in the technical parameters such as whole-process temperature control, material addition sequence, time for heating and standing static, the amount of the active carbon, active carbon absorption time, PH value of the medicinal liquid, etc.

Description

technical field [0001] The present invention relates to a glycerin fructose composition injection and a preparation method thereof, and relates to a pharmaceutical preparation for treating acute and chronic intracranial hypertension caused by cerebrovascular disease, traumatic brain injury, brain tumor, intracranial inflammation and other causes and its preparation method. The preparation method belongs to the technical field of medicine preparation. Background technique [0002] Acute and chronic intracranial hypertension caused by cerebrovascular disease, traumatic brain injury, brain tumor, intracranial inflammation and other causes are common diseases in clinical practice. Due to the great differences in patients' symptoms, age, gender, physical fitness and disease course, etc., Selecting the appropriate drug to reduce intracranial pressure is a difficult problem often encountered by clinicians. At present, the drugs commonly used in clinic to reduce intracranial pressu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/047A61K31/7004A61K9/08A61P3/12A61P7/10A61P43/00
Inventor 庄洪波
Owner AOLING BODA MEDICINE SCI & TECH DEV BEIJING