Curculigo orchioides extract, preparation method and uses thereof

A kind of technology of extract and curcuma, applied in the field of extract and preparation thereof

Inactive Publication Date: 2009-01-14
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on the preparation method of curculigoside monomer, and the effect of curculigoside on cardiovascular and cerebrovascular diseases has not been reported. Based on this, the inventor provides a kind of curculigoside extract and Its preparation method and application in medicine for preventing or treating cardiovascular and cerebrovascular diseases

Method used

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  • Curculigo orchioides extract, preparation method and uses thereof
  • Curculigo orchioides extract, preparation method and uses thereof
  • Curculigo orchioides extract, preparation method and uses thereof

Examples

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preparation example 1

[0019] Preparation Example 1: Preparation of Curculigo curculigo Extract

[0020] Curculigo curculigo 50Kg, add 600L of water, soak for 2 hours, heat and decoct 3 times, 2 hours each time, filter, combine and extract the filtrate, concentrate under reduced pressure until the relative density is 1.20 (measured at 40°C), add 95% ethanol, stir , until the ethanol concentration is 70%, let it stand for 1 hour, filter the ethanol solution, wash the filter residue with a small amount of ethanol, discard the filter residue, and concentrate the filtrate to no ethanol. The concentrated solution was loaded onto the AB-8 macroporous resin column, adsorbed, eluted with 10% ethanol solution for 3 times the column volume, discarded the eluate, eluted with 30% ethanol solution for 3 times the column volume, received the eluate, and concentrated to Ethanol free. The concentrated solution was loaded onto a polyamide resin column, adsorbed, washed with water for 5 times the column volume, disc...

preparation example 2

[0021] Preparation Example 2: Preparation of Curculigo curculigo Extract

[0022] Curculigo curculigo 50Kg, add water 500L, soak for 2 hours, heat and decoct 3 times, each time for 2 hours, filter, combine and extract the filtrate, concentrate under reduced pressure until the relative density is 1.15 (measured at 40°C), add 95% ethanol, stir , until the alcohol concentration is 60%, let it stand for 6 hours, filter the ethanol solution, wash the filter residue with a small amount of ethanol, discard the filter residue, and concentrate the filtrate to no ethanol. The concentrated solution was loaded onto the HZ-818 macroporous resin column, adsorbed, and eluted with water and 20% ethanol respectively for 3 times the column volume, discarded the eluate, eluted with 40% ethanol for 3 times the column volume, and received the eluate , concentrated to no ethanol. The concentrated solution was loaded onto a polyamide resin column, adsorbed, washed with water for 4 times the column ...

preparation example 3

[0023] Preparation Example 3: Preparation of Curculigoside Injection:

[0024] prescription:

[0025] Curculigoside 25g

[0026] Sodium chloride 89g

[0027] Water for injection 10000ml

[0028]

[0029] Made into 10000ml

[0030] Preparation method:

[0031] Take 25g of curculigoside and 89g of sodium chloride according to the prescription, dissolve it with 10,000ml of water for injection, stir; add 50g of activated carbon, stir for 20 minutes, filter the solution through a microporous membrane, and pack it into 125ml infusion bottles, 100mL per bottle , sterilized, and packed after passing the inspection. Other inspection items should meet the requirements for injection items in the Pharmacopoeia of the People's Republic of China 2005 Edition.

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Abstract

The present invention provides a rhizoma curculiginis extract, a preparation method and the applications thereof, in particular to a rhizoma curculiginis extract; wherein, the ratio of the glycoside of the rhizoma curculiginis is more than or equal to 90 percent, and less than 100 percent. And the present invention provides a preparation method of the extract, a medicine composition with the extract as an active ingredient, and an application of the medicine composition in preparation of the medicine which is used for treating or preventing cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The present invention relates to an extract, its preparation method and application, in particular to a Curculigo curculigo extract, its preparation method and its application in the preparation of medicines for treating or preventing cardiovascular and cerebrovascular diseases. Background technique [0002] Curculigo orchioides Gaertn is the dry rhizome of Curculigo orchioides Gaertn, which has the functions of invigorating kidney yang, strengthening muscles and bones, and dispelling cold and dampness. Modern phytochemical research reveals that Curculigoside contains curculigoside, curculigoside B-C, curculigosaponins A-M, orcinol glucoside and other components. At present, there is no literature report on the preparation method of curculigoside monomer, and there is no report on the effect of curculigoside on cardiovascular and cerebrovascular diseases. Based on this, the inventor provides a kind of curculigoside extract and Its preparation method a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P9/10A61K125/00
Inventor 蒋王林刘广马成俊王春明侯建耿桂华
Owner SHANDONG LUYE PHARMA CO LTD
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