A preparation method of biocompatible vascular stent or heart valve surface coating

Abstract

A preparation method of a biocompatible vascular stent or heart valve surface coating, the steps are: A, preparation of coating solution, dissolving heparin in deionized water, and adjusting its pH value to 7-8, And add endothelial cell growth factor to prepare heparin / growth factor solution; dissolve collagen in acetic acid solution to make collagen solution; B, dip coating: immerse the vascular stent or heart valve in the heparin / growth factor solution and apply it on its surface Dip-coat a layer of heparin / growth factor, take it out, wash it with deionized water, and dry it with nitrogen; then immerse it in the collagen solution, dip it with a layer of collagen, take it out, wash it with deionized water, and dry it with nitrogen; repeat the above heparin Heparin / growth factor and collagen dip-coating steps 1-60 times; finally, the above heparin / growth factor dip-coating steps are performed again to obtain. The blood vessel stent or heart valve prepared by the method has good biocompatibility and low preparation cost.

Description

Technical field [0001] The invention relates to a method for biochemically modifying the surface of a vascular stent and a heart valve material. Background technique [0002] The incidence of cardiovascular disease is increasing year by year. Atherosclerosis causes stenosis or obstruction of the lumen is the main cause of ischemic heart disease (coronary heart disease); heart valve disease is due to congenital or acquired reasons The resulting heart valve disease causes heart blood flow disorder-based disease. [0003] The latest research proves that endothelial cells are very important for the function of blood vessels: 1) The intact endothelial cell layer will secrete nitric oxide and other molecules to inhibit the excessive proliferation of smooth muscle, and the secretion mechanism of the damaged endothelial cell layer is out of balance, leading to the excessive proliferation of smooth muscle and resulting in vascular 2) The intact endothelial cell layer will secrete an...

AI Technical Summary

Problems solved by technology

But there are still some problems: with the prolongation of drug-coated stent implantation, the drug inhibits the proliferation of smooth muscle cells (the main cause of restenosis) and also inhibits the proliferation of endothelial cells, and the surface of the stent cannot form a complete endothelium. The anticoagulant function on the surface of the stent is poor; and the final drug release is exhausted and the complete endothelial cell layer that has the anticoagulant effect and inhibits the proliferation of smooth muscle cells is still not formed, and the possibility of restenosis in the vascular stent thereafter is significantly increased

[0005] At present, there are about 200,000 patients in our country who need artificial heart valve replacement surgery every year due to serious valvular disease. Most of these patients are young and middle-aged. If the valve cannot be replaced in time, it will cause immeasurable losses to the society.

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