Medicine composition and its preparation and application
A technology of composition and medicine, which is applied in the field of pharmaceutical composition with anti-inflammatory effect and its preparation, and can solve the problems such as anti-inflammation of Huodan Pills which are not recorded
Inactive Publication Date: 2009-03-18
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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[0103] Soak 100g patchouli leaves (20 mesh) for 30min, add 8 times the amount of distilled water to extract for 3 hours, add 6 times the amount of distilled water to extract the filter residue for 1 hour, and combine the volatile oil obtained from the second extraction (yield 4%). Mix the volatile oil with 1ml Tween-80, add distilled water to 100ml, the concentration is 0.04ml / ml, and set aside; soak 100g patchouli leaves (20 mesh) for 30min, add 8 times the amount of distilled water to extract for 3 hours, add 6 times more to the filter residue Extract with distilled water for 1 hour, combine the secondary water extracts, concentrate in a 90°C water bath to 75ml, add 1ml of Tween-80, add distilled water to 100ml, the concentration is 1.00g / ml, and set aside; 8.0g of pig gall powder is extracted by heating and refluxing with ethanol 2 times, 1h each time. Add 10 times the amount of ethanol for the first time, and 8 times the amount for the second time, combine the ethanol extr...
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The invention relates to a pharmaceutical composition with anti-inflammatory effect, a preparation method and the application thereof. The pharmaceutical composition is prepared by taking patchouli leaf and pig gall powder as raw materials, and the preparation method is as follows: 10 parts of the patchouli leaf are distilled with steam to obtain a volatile oil component of the patchouli leaf; another 10 parts of the patchouli leaf are distilled with the steam to extract water extract of the patchouli leaf; 0.8 part of the pig gall powder is heated and refluxed with 30%-70% ethanol, and filtered to obtain filtrate, and the ethanol is recovered from the filtrate which is decompressed and dried, and ground into fine powder, and the fine powder is mixed with the volatile oil of the patchouli leaf and the water extract to be made into the pharmaceutical composition. The pharmaceutical composition plays anti-inflammatory action by inhibiting the contents of histamine and prostaglandin (PGE) in inflammatory tissue during the occurrence and development processes of inflammation, and has significant activation on splenic lymphocytes and peripheral blood white cells, thus improving the ability of immunocyte to play of the anti-inflammation and immunization role.
Description
Technical field: [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition with anti-inflammatory effect and its preparation method and application. Background technique: [0002] Huodan pill is composed of Huoxiang and pig bile, which is a commonly used medicine in the clinical treatment of nasal sinusitis in traditional Chinese medicine. Its source, "Drug Standards of Guangdong Province" (1982), said it was derived from the "Golden Mirror of Medicine" in the Qing Dynasty. "Yi Zong Jin Jian" Volume 65 "Surgical Heart Method Essentials" contains Huoxiang Wan, which is given by Huoxiang Pills to treat "yellow and turbid nasal discharge when in the nasal orifice". Male boar bile and pills, as big as phoenix seeds. Five qian per serving, after eating Xanthium seed soup, or rice wine." The sixth volume of "Dictionary of Traditional Chinese Medicine Prescriptions" received the Qishou Huoxiang soup strips, Yun Fangyuan It was pub...
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IPC IPC(8): A61K36/53A61P29/00A61K35/413
Inventor 胡丽萍
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE