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Method for separating sclareol

A technology for the separation of sclareol and its separation method, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of low production efficiency, high cost, and large energy consumption, and achieve low cost and short heating time. Short, low energy consumption effect

Active Publication Date: 2011-07-20
西安天美生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention provides a method for separating sclareol to overcome the problems of low production efficiency, low yield, large energy consumption and high cost in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A method for separating sclareol, comprising the steps successively:

[0016] (1) Pre-treatment: Add 200kg of Clarisula extract with a content of 45.2% into the distillation kettle and heat to 85-90 degrees to melt to a liquid state. Use a centrifugal extractor with a heat preservation system at a temperature of 150°C and 2000 rpm Centrifugal extraction at a high speed to remove heavy phases (mainly external impurities, high-polarity, high-density, high-melting point extracts and other impurities, some of which are very harmful to the normal operation of the molecular still);

[0017] (2) One-stage distillation: After the pretreatment is completed, the initial extract is added to the molecular still, and the pressure is maintained at 130 Pa, and the temperature is 200 degrees. After distillation, the crude extract is divided into a heavy phase (waste impurities) and a light phase (higher content of Clarissus crude extract), the heavy phase is directly discharged through...

Embodiment 2

[0020] A method for separating sclareol, comprising the steps successively:

[0021] (1) Pre-treatment: Add 260kg of Clarisula extract with a content of 48.6% into the distillation pot and heat it to 90-95 degrees to melt to a liquid state. Use a centrifugal extractor with a heat preservation system at a temperature of 135°C and 5000 rpm Centrifugal extraction at a high speed to remove the heavy phase;

[0022] (2) One-stage distillation: After the pretreatment is completed, add the initial extract to the molecular still, keep the pressure at 140 Pa, and the temperature at 205 degrees. After distillation, the crude extract is divided into heavy phase and light phase, and the heavy phase is directly discharged through a special pipeline. discarded, the light phase enters the secondary distillation;

[0023] (3) secondary distillation: the light phase that step (2) obtains adds the molecular still of normal operation, and molecular still maintains pressure 60 Pa, and temperatur...

Embodiment 3

[0025] A method for separating sclareol, comprising the steps successively:

[0026] (1) Pre-treatment: Add 150kg of Clarisula extract with a content of 50.2% into the distillation pot and heat it to 150-155 degrees to melt to a liquid state. Use a centrifugal extractor with a heat preservation system at a temperature of 150°C and 1000 rpm Centrifugal extraction at a high speed to remove the heavy phase;

[0027] (2) One-stage distillation: After the pretreatment is completed, add the initial extract to the molecular still, keep the pressure at 110 Pa, and the temperature at 195 degrees. After distillation, the crude extract is divided into heavy phase and light phase, and the heavy phase is directly discharged through a special pipeline. discarded, the light phase enters the secondary distillation;

[0028] (3) secondary distillation: the light phase that step (2) obtains adds the molecular still of normal operation, and molecular still maintains pressure 40 Pa, and temperat...

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Abstract

The invention relates to the technical field of natural perfume separation, in particular to a separation method of sclareol. The invention overcomes the problems in the prior art that the production efficiency is low, the yield is low, the energy consumption is great and the cost is high. Aiming at overcoming the problems in the prior art, the technical proposal of the invention is as follows: the separation method of the sclareol comprises the following steps sequentially: (1) preliminary treatment: the crude extract of sage clary is heated to be fully melted, and centrifugal extraction is carried out to remove heavy phase substances; (2) primary stage of distillation: the crude extract of the sage clary is sent to a molecular still, after continuous distillation, the extract is dividedinto heavy phase and light phase, wherein, the light phase is carried out with secondary distillation; and (3) secondary distillation: the light phase obtained in the step (2) is sent to the molecular still again to obtain the sclareol with the concentration of 90 to 98 percent. Compared with the prior art, the method has the advantages of high production efficiency, high yield reaching more than95 percent, low energy consumption and low cost.

Description

Technical field: [0001] The invention relates to the technical field of separation of natural spices, in particular to a separation method of sclareol. Background technique: [0002] Sclareol is extracted from the inflorescence of Sclare (Salvia Sclare L.), and has many physiological activities such as antibacterial and acne elimination. At present, the method commonly used in this industry is: use the crude extract of Clary Perilla as raw material, and separate it by vacuum distillation or solvent extraction. The solvent extraction method needs to use a large amount of solvent for repeated crystallization, and the escape and leakage of the solvent It is not only a dangerous factor for safe production, but also causes great pressure on the environment. Although vacuum distillation can reduce environmental pollution, it also has the following problems: 1. Low production efficiency: the heating process in vacuum distillation requires at least 12 hours; 2. Low yield: the produ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C29/80C07C35/36
Inventor 刘静胡永卫王朝晖
Owner 西安天美生物科技股份有限公司
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