Dry powder inhalation device for the simultaneous administration of more than one medicament

Abstract

The present invention relates to a dry powder inhalation device which is suitable for the simultaneous administration of a combination of pharmaceutical ingredients, wherein each pharmaceutical ingredient is packed in a separate blister of the same single dose blister strip. The medicaments that form the combination come into contact just before their exit from the mouthpiece of the device.

Description

technical field [0001] The present invention relates to a dry powder inhaler device suitable for the simultaneous administration of a combination of different medicaments, wherein each medicament is packed in individual blisters of a single-dose blister strip. Background technique [0002] Administration by inhalation is one of the most successful methods that can be applied in therapy for a wide variety of diseases. Initially inhaled medicaments were used to treat diseases affecting the airways; however recently the development of inhaled forms of medicaments against various other diseases such as diabetes has attracted increasing attention. [0003] Administration by inhalation is performed by using an inhalation device (inhaler). The state of the art includes a large number of such devices. Many types of inhalers include those in which the medicament is in the form of a dry powder in a reservoir and in which the patient, by using the power of his / her lungs, generates an...

AI Technical Summary

Problems solved by technology

[0005] However, the presence of mixtures of active ingredients in pharmaceutical compositions creates considerable problems

Firstly there is the possibility of interactions between the active ingredients included in the mixture, which can lead to their decomposition

This result at best results in a less effective treatment due to the presence of less active ingredient in each dose, and at worst the patient may be at risk because the breakdown products are not only not curative but also May pose a threat to the patient's health

Furthermore, the presence of mixtures of active ingredients creates problems with the development of suitable pharmaceutical compositions, since each active ingredient has its own physical and chemical properties, which are not necessarily compatible with the corresponding properties of the other ingredients

Therefore, the development of a pharmaceutical composition suitable for the two components of the mixture becomes more difficult

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