Edulcoration purification process for rhizoma paris saponin extract solution

The technology of Chonglou saponin and extract is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as low efficiency, and achieve the effects of easy operation, simple process and high content

Inactive Publication Date: 2009-04-08
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The process involves two processes,

Method used

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  • Edulcoration purification process for rhizoma paris saponin extract solution
  • Edulcoration purification process for rhizoma paris saponin extract solution
  • Edulcoration purification process for rhizoma paris saponin extract solution

Examples

Experimental program
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Effect test

Embodiment 1

[0049]Example 1: Take 100 kilograms of dried rhizomes of Yunnan Zhonglou, crush them into coarse powder, extract them with 1,000, 500, and 500 kilograms of 70% ethanol for 5, 4, and 3 hours respectively, combine the extracts, and filter to remove impurities such as medicine residue and mud , The crude extract of saponins from Chonglou saponins is obtained, and the organic solvent is recovered after concentration under reduced pressure. 1g of amylase or pectinase is added to each liter of concentrated solution to make a suspension, and the ethanol content in the suspension is controlled to be less than 5 %, the final solution density is 1.01 (measured with a densimeter at 25°C) and the volume is 0.40 cubic meters. The suspension was filtered with an inorganic ceramic membrane, the ceramic membrane material was zirconium dioxide (ZrO2) membrane, the membrane pore size was 0.05μm, the retentate was collected, concentrated, and dried to obtain 5.4 kg of the extract of saponins of sapo...

Embodiment 2

[0050] Example 2: Take 80 kilograms of dried rhizomes of Yunnan Zhonglou, crush them into coarse powder, extract them with 800, 400, and 400 kilograms of 60% ethanol for 5, 4, and 3 hours respectively, combine the extracts, and filter to remove impurities such as slag and mud , The crude extract of saponins from Chonglou saponins is obtained, and the organic solvent is recovered after concentration under reduced pressure. 2g of amylase or pectinase is added to each liter of concentrated solution to make a suspension, and the ethanol content in the suspension is controlled to be less than 7 %, the final solution density is 1.01 (measured with a densimeter at 25°C) and the volume is 0.35 cubic meters. The suspension was filtered with an inorganic ceramic membrane. The material of the ceramic membrane was a zirconium dioxide (ZrO2) membrane with a pore size of 0.05μm. The retentate was collected, concentrated, and dried to obtain 4.0 kg of the extract of the saponins of the saponins ...

Embodiment 3

[0051] Example 3: Take 50 kilograms of dried rhizomes of Aesculus vulgaris, crush them into coarse powder, extract them with 500, 400, and 400 kilograms of 80% ethanol for 8, 5, and 3 hours respectively, combine the extracts, and filter to remove medicine residues, silt, etc. Impurities, the crude extract of saponins from Chonglou saponins is obtained, and the organic solvent is recovered after concentration under reduced pressure. 3g of amylase or pectinase is added to each liter of concentrated solution to make a suspension, and the ethanol content in the suspension is controlled to be lower than 10%, so that the final solution density is 1.02 (measured with a densimeter at 25°C) and the volume is 0.15 cubic meters. The suspension was filtered with an inorganic ceramic membrane, the ceramic membrane material was zirconium dioxide (ZrO2) membrane, the membrane pore size was 0.10μm, the retentate was collected, concentrated, and dried to obtain 2.3 kg of Chonglou saponin extract, ...

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Abstract

The invention relates to a method for carrying out impurity removal and purification on an extracting solution containing effective plant compositions. The method for carrying out impurity removal and purification on an extracting solution of Paris rhizome saponin comprises the following steps: 1. a Paris rhizome plant is pulverized into coarse powders; the coarse powders are extracted through a menstruum, and is filtered,; residue and impurity are removed to obtain coarse extracting solution of the Paris rhizome saponin; and the menstruum is a mixture of water and one or more than one of organic solvents of methanol, ethanol, acetone, normal butanol, ethyl acetate and chloroform; 2. the coarse extracting solution obtained in the step one is condensed to a suspending solution with density between 1.01 and 1.05 at the temperature of 25 DEG C; and 3. the suspending solution is filtered through an inorganic ceramic film of which the material is a zirconium dioxide film with film aperture of between 0.05 and 0.2 mu m; a trapped solution and a permeated solution are obtained; and the trapped solution is collected to obtain the extracting solution of the Paris rhizome saponin after impurity removal and purification. Compared with the prior impurity removal and purification method of the Paris rhizome saponin, the method is simple and easy to operate; and the obtained extract has high contents of active compositions (Paris rhizome saponin), low hygroscopic property and the like.

Description

Technical field [0001] The invention relates to a method for removing impurities and purifying an extract containing plant effective ingredients. Background technique [0002] As a modern purification technology, inorganic ceramic membrane separation technology has shown excellent development prospects in the field of separation and impurity removal of plants and Chinese medicinal materials, involving the preparation of injections, oral liquids, extracts, medicinal wines and other dosage forms. The permeate obtained by the inorganic ceramic membrane microfiltration in the aspects of sterilization and pyrogen removal can make the product meet the quality standard requirements. In addition, some people use inorganic ceramic membranes to pre-treat the material liquid, collect the permeate on the macroporous resin column, and remove the insoluble components such as polysaccharides, pectin, starch, and fiber in the extracted material liquid. It is smooth and not easy to agglomerate in...

Claims

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Application Information

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IPC IPC(8): A61K36/896
Inventor 赵守仁王真韦建荣张峰张新华
Owner YUNNAN BAIYAO GROUP
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