Automatic separating method for X type overlapping and adhering chromosome

Abstract

The invention provides a method used for automatically cutting X-typed overlapped and conglutinated chromosomes, comprising the steps as follows: step 1: binarization segmentation processing is carried out to a chromosome image so as to obtain a binarization template; step 2: the X-typed overlapped chromosome image is extracted from the template, the chromosome profile is obtained by a gradient operator and treated with Freeman chain coding so as to obtain a boundary chain code; step 3: the overlapped chromosome is processed by thinning algorithm so as to extract a single-pixel framework and determine the central point of an overlapping area; and step 4: the distance from the profile pixel point to the central point of the overlapping area after the Freeman chain code is calculated; four profile concave points which are not adjacent to each other are selected as cutting points so as to divide the profile into two profile sets; and the segmented chromosome profile sets are used for automatically completing the operation of segmenting the chromosome grey images, thus obtaining the automatic segmenting result of the X-typed overlapped and conglutinated chromosome. The method has quick and effective cutting operation and greatly reduces the working quantity and difficulty of manpower segmentation.

Description

technical field [0001] The invention relates to an automatic segmentation method for X-shaped overlapping and cohesive chromosomes, in particular to an automatic segmentation method for overlapping and cohesive chromosomes of a chromosome analysis system based on a camera and a microscope. Background technique [0002] With the continuous integration and development of multimedia communication technology and video information application in the field of modern medicine, the diagnosis and treatment of hospitals are increasingly dependent on modern multimedia digital medical examination results. The application of imaging examinations such as microscopes, X-ray examinations, CT, MRI, ultrasound, gastroenteroscopy, and speculum is becoming more and more common. Digital medicine refers to the digitalization, networking and informatization of medical services. Through computer science and modern network communication technology and database technology, it provides the collection,...

AI Technical Summary

Problems solved by technology

Although some of these chromosome automatic analysis systems have good results, they have not reached a satisfactory level, especially in the segmentation of chromosome overlap and cohesion images, chromosome feature extraction and band analysis. The effect of system analysis is limited to varying degrees, and it is not yet possible to realize automatic analysis in the true sense

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