Automatic separating method for X type overlapping and adhering chromosome

An automatic segmentation and chromosome technology, which is applied in the analysis of materials, image analysis, and material analysis through optical means, etc., can solve the problems of system analysis effect limitation, chromosome feature extraction and band analysis difficulties, automatic analysis cannot be realized, etc. To achieve the effect of increasing the degree of automation

Inactive Publication Date: 2009-04-08
GUANGDONG VTRON TECH CO LTD
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Problems solved by technology

Although some of these chromosome automatic analysis systems have good results, they have not reached a satisfactory level, especially in the segmentation of chromosome overlap and cohesion i

Method used

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  • Automatic separating method for X type overlapping and adhering chromosome
  • Automatic separating method for X type overlapping and adhering chromosome
  • Automatic separating method for X type overlapping and adhering chromosome

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Embodiment

[0037] Utilize the present invention to realize the flow chart of automatic segmentation of X-type overlapping and cohesive chromosomes as follows Figure 14 Shown:

[0038] first step: image 3 It is an original image of chromosome collected by microscope. image 3 The chromosome image shown is preprocessed to remove miscellaneous information and noise such as noise and bubbles generated during the acquisition process. image 3 Perform median filtering, and then perform grayscale stretching processing, the preprocessing results are as follows Figure 4 shown by Figure 4 It can be seen that part of the noise and bubbles generated during the acquisition process are eliminated, and the contrast of the inner region of the chromosome is increased, making the banding features clearer, but there are still some bubbles. Then, through the gray histogram of the statistical image, it is found that the number of background gray pixels is more than the sum of the foreground gray. Th...

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Abstract

The invention provides a method used for automatically cutting X-typed overlapped and conglutinated chromosomes, comprising the steps as follows: step 1: binarization segmentation processing is carried out to a chromosome image so as to obtain a binarization template; step 2: the X-typed overlapped chromosome image is extracted from the template, the chromosome profile is obtained by a gradient operator and treated with Freeman chain coding so as to obtain a boundary chain code; step 3: the overlapped chromosome is processed by thinning algorithm so as to extract a single-pixel framework and determine the central point of an overlapping area; and step 4: the distance from the profile pixel point to the central point of the overlapping area after the Freeman chain code is calculated; four profile concave points which are not adjacent to each other are selected as cutting points so as to divide the profile into two profile sets; and the segmented chromosome profile sets are used for automatically completing the operation of segmenting the chromosome grey images, thus obtaining the automatic segmenting result of the X-typed overlapped and conglutinated chromosome. The method has quick and effective cutting operation and greatly reduces the working quantity and difficulty of manpower segmentation.

Description

technical field [0001] The invention relates to an automatic segmentation method for X-shaped overlapping and cohesive chromosomes, in particular to an automatic segmentation method for overlapping and cohesive chromosomes of a chromosome analysis system based on a camera and a microscope. Background technique [0002] With the continuous integration and development of multimedia communication technology and video information application in the field of modern medicine, the diagnosis and treatment of hospitals are increasingly dependent on modern multimedia digital medical examination results. The application of imaging examinations such as microscopes, X-ray examinations, CT, MRI, ultrasound, gastroenteroscopy, and speculum is becoming more and more common. Digital medicine refers to the digitalization, networking and informatization of medical services. Through computer science and modern network communication technology and database technology, it provides the collection,...

Claims

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Application Information

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IPC IPC(8): G01N33/48G01N21/84G06T7/60G06T7/40
Inventor 林道庆杨月
Owner GUANGDONG VTRON TECH CO LTD
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