Cholesterin derivative, as well as preparation method and application thereof

A technology of cholesterol and derivatives, which is applied in the field of cholesterol derivatives and their preparation, and achieves the effect of broad application prospects

Active Publication Date: 2011-06-29
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] So far, there is no report on the chemical compositi

Method used

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  • Cholesterin derivative, as well as preparation method and application thereof
  • Cholesterin derivative, as well as preparation method and application thereof
  • Cholesterin derivative, as well as preparation method and application thereof

Examples

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Embodiment Construction

[0011] In preparing the compounds of the present invention, the following steps are taken:

[0012] (1) Extraction of biological sample: get fresh biological sample bud gorgonian gorgonian 2850g, clean with tap water, remove silt, first use 3L 95% (mass percentage, the same below) ethanol lixiviation after this sample pulverization 3 times, 1d each time. The three extracts were combined, evaporated to dryness by rotary evaporation, desalted three times with 2L methanol, and concentrated under reduced pressure to obtain the total extract. After the total extract was diluted with 500mL of water, it was extracted 6 times with equal volumes of petroleum ether, ethyl acetate and n-butanol, and the extract was concentrated under reduced pressure to obtain petroleum ether, ethyl acetate and n-butanol extracts, and each extract was sealed and stored in Store in the refrigerator at 4°C for later use.

[0013] Described ethanol can change methyl alcohol, Virahol or n-butanol into.

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Abstract

The invention discloses a cholesterol derivative with 19-bit methyl oxidized into carboxyl, and a preparation method and application thereof; during preparation, bud-dichasial junceella juncea is firstly extracted by alcohol; the extract is decompressed and concentrated to obtain an extractum; the extractum suspends in water and then extracted by an organic solvent to obtain extract liquid; afterbeing decompressed and concentrated, the extract liquid is separated by chromatography of silicagel columns, gel chromatography and high-performance liquid phase chromatography to obtain the cholesterol derivative with 19-bit methyl oxidized into the carboxyl. The cholesterol derivative with 19-bit methyl oxidized into the carboxyl and derived from the bud-dichasial junceella juncea has stronger insecticidal activity and can be used for developing biological agricultural chemicals, thus having broad application prospect.

Description

technical field [0001] The invention relates to a cholesterol derivative, in particular to a cholesterol derivative with an insecticidal effect in which the methyl group at the 19th position is oxidized to a carboxyl group, a preparation method and application thereof. Background technique [0002] Since the 1960s, many active compounds with novel structures have been isolated from gorgonians, mainly including diterpenoids, steroids, alkaloids, etc., and their biological activities include antitumor, antibacterial, antiviral, enzyme inhibition, etc. The chemical composition of gorgonians has become a hot area of ​​marine natural product research. [0003] So far, there is no report on the chemical composition of Dichotella gemmacea (valenciennes) at home and abroad. Not to mention the cholesterol derivatives in which the methyl group at the 19th position is oxidized to a carboxyl group have not been isolated from Cordica difidota, nor have such derivatives been isolated fr...

Claims

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Application Information

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IPC IPC(8): C07J9/00A01N45/00A01P7/00
Inventor 王长云邵长伦牟海津刘海燕管华诗
Owner OCEAN UNIV OF CHINA
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