Cholesterin derivative, as well as preparation method and application thereof

Abstract

The invention discloses a cholesterol derivative with 19-bit methyl oxidized into carboxyl, and a preparation method and application thereof; during preparation, bud-dichasial junceella juncea is firstly extracted by alcohol; the extract is decompressed and concentrated to obtain an extractum; the extractum suspends in water and then extracted by an organic solvent to obtain extract liquid; afterbeing decompressed and concentrated, the extract liquid is separated by chromatography of silicagel columns, gel chromatography and high-performance liquid phase chromatography to obtain the cholesterol derivative with 19-bit methyl oxidized into the carboxyl. The cholesterol derivative with 19-bit methyl oxidized into the carboxyl and derived from the bud-dichasial junceella juncea has stronger insecticidal activity and can be used for developing biological agricultural chemicals, thus having broad application prospect.

Description

technical field

[0001] The invention relates to a cholesterol derivative, in particular to a cholesterol derivative with an insecticidal effect in which the methyl group at the 19th position is oxidized to a carboxyl group, a preparation method and application thereof. Background technique

[0002] Since the 1960s, many active compounds with novel structures have been isolated from gorgonians, mainly including diterpenoids, steroids, alkaloids, etc., and their biological activities include antitumor, antibacterial, antiviral, enzyme inhibition, etc. The chemical composition of gorgonians has become a hot area of ​​marine natural product research.

[0003] So far, there is no report on the chemical composition of Dichotella gemmacea (valenciennes) at home and abroad. Not to mention the cholesterol derivatives in which the methyl group at the 19th position is oxidized to a carboxyl group have not been isolated from Cordica difidota, nor have such derivatives been isolated fr...

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