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Chinese medicine granules containing Anemarrhena asphodefoides extract and preparation method thereof

A technology of Anemarrhena extract and traditional Chinese medicine granules, which can be applied to medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., and can solve problems such as unsightly appearance, poor taste, and low drug loading of granules

Active Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 1. Extraction of extractum of the present invention: Atractylodes atractylodis 6kg, water steam distillation method extracts atractylodes atractylodes volatile oil, dregs continue to extract, filter, the lower layer of medicinal liquid is standby, and the upper layer atractylodes atractylodes volatile oil adopts β-CD clathrate, clathrate for subsequent use. Add 10kg of dregs and Anemarrhena, 6kg of Puhuang, 6kg of Dijincao, 1kg of Coptis chinensis and other four medicinal materials, add water and decoct twice, decoct for 2 hours for the first time, decoct for 1 hour for the second time, combine the decoction liquid, Filtrate, combine the filtrate with the above-mentioned lower layer liquid medicine, concentrate to a relative density of 1.02-1.05 (80°C), add 95% (ml / ml) ethanol to make the ethanol concentration 50% (ml / ml), let it stand, and filter , recover ethanol to a relative density of 1.15-1.20 (60°C), and set aside.

[0048] 2. Preparation of masterbatch

[0049]...

Embodiment 2

[0062] Preparation of the active ingredient of the present invention: take 833g of Anemarrhena, 500g of Atractylodes atractylodes, 500g of Puhuang, 500g of Dijincao, and 83g of Coptis chinensis; extract the volatile oil of Atractylodes atractylodes for 5 hours by steam distillation, and clathrate the volatile oil of Atractylodes atractylodes with β-cyclodextrin. Oil and β-cyclodextrin are fed at a ratio of 1:6, dried at 50°C to obtain β-cyclodextrin inclusion compound for later use, and the extract is filtered to obtain filtrate 1; , Puhuang, Dijincao and Atractylodes atractylodes, add 8 times the amount of water to decoct twice, decoct for 2 hours for the first time, decoct for 1 hour for the second time, combine the two decoctions, and filter to obtain the filtrate 2 , combine the filtrates 1 and 2, concentrate the filtrate at room temperature to form a clear ointment with a specific gravity of 1.10-1.15; add β-cyclodextrin inclusion compound to the clear ointment to prepare ...

Embodiment 3

[0066] Preparation of the active ingredient of the present invention: take 416g of Anemarrhena, 350g of Atractylodes atractylodes, 250g of Puhuang, 250g of Dijincao, and 50g of Coptis chinensis; extract the volatile oil of Atractylodes atractylodes for 5 hours by steam distillation, and clathrate the volatile oil of Atractylodes atractylodes with β-cyclodextrin. Oil and β-cyclodextrin are fed at a ratio of 1:6, dried at 50°C to obtain β-cyclodextrin inclusion compound for later use, and the extract is filtered to obtain filtrate 1; Anemarrhena, Coptidis, Puhuang and Dijincao And add 8 times the amount of water to decoct the residue after Atractylodes atractylodis extract, decoct twice, decoct for 2 hours for the first time, decoct for 1 hour for the second time, combine the two decoctions, filter to obtain filtrate 2, and combine filtrates 1 and 2, Concentrating the filtrate at room temperature to form a clear ointment with a specific gravity of 1.10-1.15; adding β-cyclodextrin...

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Abstract

The invention provides traditional Chinese medicine granular preparation containing rhizoma anemarrhenae extractive and a preparation method thereof. In the invention, traditional Chinese medicine spheroidized particles are prepared by traditional Chinese medicine extractive and carriers acceptable in pharmacy. The outline of the traditional Chinese medicine spheroidized particles takes sphere shape or round type shape. The density of the preparation is 0.6-1.3 g / ml. The spheroidized particles of the invention have low single dose, are convenient in use, can be served as intermediate products of capsules, and also can be used for developing traditional Chinese medicine controlled release preparation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing an anemarrhena extract and a preparation method thereof. Background technique [0002] Diabetes belongs to the category of diabetes mellitus in the motherland. It is a chronic progressive lifelong disease with long course of disease, complicated pathological changes and many complications. The lesions not only involve the heart, brain, liver, liver, but also the tendons, bones, skin, and muscles of the whole body after the development of the lungs, stomach, and kidneys. The current treatment of this disease, as well as the prevention and treatment of its complications, are quite thorny issues in modern medicine. Now most of the treatment of diabetes is based on Western medicine. Western medicine mostly uses drugs such as sulfonylureas, biguanides and insulin to treat diabetes. Although...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61K9/16A61P3/10
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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