Vitamin C precursor liposome and preparation method thereof

A pro-liposome and vitamin technology, applied in the directions of liposome delivery, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of vitamin C liposome content limitation, influence effect, instability, etc., and achieve improved stability. performance, ease of operation, and the effect of solving aggregation

Active Publication Date: 2009-07-08

LB COSMECEUTICAL TECH CO LTD +1

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AI-Extracted Technical Summary

Problems solved by technology

[0004] 1. Liposome, as a colloidal particle, is a thermodynamically unstable system, which is prone to aggregation, fusion, sedimentation, oxidative decomposition of phospholipids, and leakage of encapsulated drugs in aqueous solution, resulting in liposome instability;

[0005] 2. The instability of vitamin C structure makes it more unstable in aqueous solution;

[0006] 3. The content of vitamin C liposome...

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Abstract

The invention relates to the technical fields of medicament and cosmetics, in particular to a vitamin C proliposome and a preparation method thereof. The vitamin C proliposome can be used for preparing a transdermal preparation and cosmetics. The vitamin C proliposome is a solid granular preparation which ensures that the stabilities of the vitamin C and the proliposome are improved, and the vitamin C proliposome can revert to a vitamin C lipidosome only by adding a small amount of water or aqueous solution for hydration before the vitamin C proliposome is in use, and thereby, a sufficient amount of vitamin C lipidosome is added into the transdermal preparation and the cosmetics according to need so that the content of the vitamin C in the transdermal preparation and the cosmetics reaches the required dosage, and thereby, the efficacy is improved.

Application Domain

Organic active ingredientsCosmetic preparations +7

Technology Topic

Aqueous solutionLiposome +4

Image

Examples

Experimental program(20)
Effect test(1)

Example Embodiment

[0028] Example 1:

[0029] Take 10 g of vitamin C, 30 g of soy lecithin, 30 g of cholesterol, 40 g of poloxamer, 200 g of glucose, and 200 mL of chloroform.

[0030] Add the liposome skeleton material soy lecithin, poloxamer, and cholesterol to a 1000 mL round bottom flask, dissolve the liposome skeleton material with chloroform, and place it in a constant temperature water bath at 25~40℃ to evaporate the film on a rotary film. A lipid film is formed at the bottom of the bottom flask for use; dissolve glucose and vitamin C in 800 mL of water, filter, pour the filtrate into the above round bottom flask, hydrate, shake, add water to the total volume of the mixed liquid to 1000 mL, and homogenize Treatment (8000 psi, 3 times) to obtain liposome suspension, and freeze-drying (temperature -50°C, vacuum degree 100 mtorr) to obtain vitamin C precursor liposome.

Example Embodiment

[0031] Example 2:

[0032] Vitamin C100g, egg yolk lecithin 50g, cholesterol 50g, sucrose 40g.

[0033] Put egg yolk lecithin and cholesterol in a Erlenmeyer flask, heat and melt them, and place them in a constant temperature water bath at 80°C for later use; dissolve sucrose and vitamin C with 800 mL of water, filter, heat the filtrate in a water bath to the same temperature as the lipid solution, The lipid solution was shaken and mixed, cooled, and water was added until the total volume of the mixed liquid was 1000 mL. After homogenization (12000 psi, twice), a liposome suspension was obtained, which was spray-dried as usual to obtain vitamin C precursor lipid body.

Example Embodiment

[0034] Example 3:

[0035] Vitamin C50g, polydioxyethylene cetyl ether 60g, stigmasterol 40g, poloxamer 50g, trehalose 80g, ether 200mL.

[0036] Add polydioxyethylene cetyl ether and cholesterol to a 500mL Erlenmeyer flask, add ether to dissolve them for later use; Dissolve trehalose, poloxamer and vitamin C with 800mL of water, filter, and pour the filtrate into the triangle Place the flask in a 45°C constant temperature water bath, magnetically stir, at a stirring speed of 500rpm, and volatilize the organic solvent to obtain a liposome suspension. After freeze-drying (temperature -50°C, vacuum degree 80mtorr), vitamin C precursor fat is obtained Plastid.

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Description & Claims & Application Information

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