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Vitamin C precursor liposome and preparation method thereof

A pro-liposome and vitamin technology, applied in the directions of liposome delivery, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of vitamin C liposome content limitation, influence effect, instability, etc., and achieve improved stability. performance, ease of operation, and the effect of solving aggregation

Active Publication Date: 2009-07-08
LB COSMECEUTICAL TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. Liposome, as a colloidal particle, is a thermodynamically unstable system, which is prone to aggregation, fusion, sedimentation, oxidative decomposition of phospholipids, and leakage of encapsulated drugs in aqueous solution, resulting in liposome instability;
[0005] 2. The instability of vitamin C structure makes it more unstable in aqueous solution;
[0006] 3. The content of vitamin C liposomes in the suspension state is often limited. For some transdermal drug delivery preparations or cosmetics, the required vitamin C content is higher, but the formula cannot be mixed with too much vitamin C liposome suspension, otherwise it is too dilute, it is difficult to increase the dose of vitamin C, the insufficient dose will directly affect the effect of skin drug delivery preparations or cosmetics

Method used

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  • Vitamin C precursor liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 10g of vitamin C, 30g of soybean lecithin, 30g of cholesterol, 40g of poloxamer, 200g of glucose, and 200mL of chloroform.

[0030] Add the liposome skeleton material soybean lecithin, poloxamer, and cholesterol into a 1000mL round-bottomed flask, dissolve the liposome skeleton material with chloroform, and place it in a constant temperature water bath at 25-40°C for rotary thin-film evaporation. Form a layer of lipid film at the bottom of the bottom flask, and set aside; dissolve glucose and vitamin C in 800mL of water, filter, pour the filtrate into the above round bottom flask, hydrate, shake, add water until the total volume of the mixed liquid is 1000mL, and homogenize Treat (8000psi, 3 times) to obtain a liposome suspension, and freeze-dry (temperature -50°C, vacuum 100mtorr) to obtain vitamin C proliposome.

Embodiment 2

[0032] Vitamin C100g, egg yolk lecithin 50g, cholesterol 50g, sucrose 40g.

[0033] Put egg yolk lecithin and cholesterol in an Erlenmeyer flask, heat to melt, and place in a constant temperature water bath at 80°C for later use; dissolve sucrose and vitamin C with 800mL water, filter, heat the filtrate water bath to the same temperature as the lipid solution, and mix the aqueous solution with The lipid solution was shaken and mixed, cooled, and water was added until the total volume of the mixed liquid was 1000mL. After homogenization treatment (12000psi, twice), a liposome suspension was obtained, which was spray-dried as usual to obtain vitamin C precursor lipid body.

Embodiment 3

[0035] Vitamin C 50g, polyoxyethylene cetyl ether 60g, stigmasterol 40g, poloxamer 50g, trehalose 80g, ether 200mL.

[0036] Add polyoxyethylene cetyl ether and cholesterol to a 500mL Erlenmeyer flask, add ether to dissolve them for later use; dissolve trehalose, poloxamer and vitamin C with 800mL of water, filter, and pour the filtrate into the Erlenmeyer flask Place in the flask in a constant temperature water bath at 45°C, stir magnetically at a stirring speed of 500rpm, and volatilize the organic solvent to obtain a liposome suspension, which is freeze-dried (temperature -50°C, vacuum 80mtorr) to obtain vitamin C precursor lipid plastid.

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Abstract

The invention relates to the technical fields of medicament and cosmetics, in particular to a vitamin C proliposome and a preparation method thereof. The vitamin C proliposome can be used for preparing a transdermal preparation and cosmetics. The vitamin C proliposome is a solid granular preparation which ensures that the stabilities of the vitamin C and the proliposome are improved, and the vitamin C proliposome can revert to a vitamin C lipidosome only by adding a small amount of water or aqueous solution for hydration before the vitamin C proliposome is in use, and thereby, a sufficient amount of vitamin C lipidosome is added into the transdermal preparation and the cosmetics according to need so that the content of the vitamin C in the transdermal preparation and the cosmetics reaches the required dosage, and thereby, the efficacy is improved.

Description

technical field [0001] The invention relates to the technical field of medicine and cosmetics, and relates to a vitamin C proliposome and a preparation method thereof. The vitamin C proliposome can be used to prepare skin drug delivery preparations or cosmetics. Background technique [0002] Vitamin C is one of the essential nutrients for the human body, and it participates in various reactions in the body. Vitamin C can promote the synthesis of collagen, which is beneficial to the faster healing of tissue wounds; it is a major antioxidant that prevents free radicals from damaging the human body, and is used to prevent skin cancer. In addition, vitamin C can effectively increase the activity of skin cells, increase the elasticity and softness of the skin, prevent skin aging; inhibit tyrosinase and reduce melanin, and dilute the formed spots, inhibit the formation of melanin, and has the effect of whitening and removing spots . Therefore, vitamin C is used in the prevention...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/375A61K8/02A61K8/49A61P17/00A61P39/06A61P35/00A61Q19/08A61Q19/02A61K9/127A61K8/14
Inventor 李成亮柳郁高保安
Owner LB COSMECEUTICAL TECH CO LTD
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