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Glehnia root dispensing granule as well as preparation method and quality control method

A technology for formula granules and northern sea ginseng, which can be applied to pharmaceutical formulas, medical preparations containing active ingredients, measuring devices, etc., and can solve problems such as difficulty in spectral analysis.

Active Publication Date: 2009-07-08
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the spectra, so that conventional infrared spectroscopy has not been able to play its due role in the quality control and management of traditional Chinese medicines for a long period of time. the role of

Method used

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  • Glehnia root dispensing granule as well as preparation method and quality control method
  • Glehnia root dispensing granule as well as preparation method and quality control method
  • Glehnia root dispensing granule as well as preparation method and quality control method

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Example 1: North Radix Ginseng Formula Granules

[0037] Take 100kg of Adenophora decoction pieces, add 800kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 800kg of water to the dregs, extract for 1.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.05 —1.10; the concentrated solution is preheated at 45°C, the inlet air temperature is 180°C, the material pump speed is 550 rpm, the outlet air temperature is 80°C, and the air supply temperature is 45°C, and spray-dried to obtain the spray-dried powder of Adenophora japonicus; Add the auxiliary material dextrin of its own weight portion 0-5% in the spray-dried powder of Adenophora japonicus; The pressure of the spray-dried Adenophora japonicus powder is 5MPa on the main roller, the pressure on the side roller is 0.5MPa, and the spindle speed is 400 rpm Dry granulation under the condition that the fee...

Embodiment 2

[0038] Example 2: North Radix Ginseng Formula Granules

[0039] Take 100kg of decoction slices of Adenophora ginseng, add 1000kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 600kg of water to the dregs, extract for 1 hour, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.00 —1.05; the concentrated solution is preheated at 50°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air delivery temperature is 50°C, and spray-dried to obtain the spray-dried powder of Adenophora japonicus; Add 5-15% of its own auxiliary material dextrin in the spray-dried powder of Adenophora japonicus; the pressure of the main pressure wheel is 6MPa, the pressure of the side pressure wheel is 0.4MPa, the spindle speed is 450 rpm, and the feeding voltage is 110V dry granulation under certain conditions to obtain 20-60 ...

Embodiment 3

[0041] Embodiment 3: North Radix Ginseng Formula Granules

[0042] Take 100kg of decoction slices of Adenophora ginseng, add 1400kg of water, extract for 2.5 hours, that is, the first decoction; after the first decoction, add 1100kg of water to the dregs, extract for 2.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.10 —1.15; the concentrated solution is preheated at 45°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air delivery temperature is 50°C, and the spray-dried powder is obtained; Add 15-25% of its own weight of lactose to the spray-dried powder of Adenophora japonicus; the pressure of the main pressure wheel is 4MPa, the pressure of the side pressure wheel is 0.4MPa, the spindle speed is 500 rpm, and the feeding voltage is 130V. Dry granulation method to obtain 20-60 mesh Adenophora granules formula, each gram of Ade...

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Abstract

The invention discloses a coastal glehnia root prescription granule and a preparation method and a quality control method thereof. The prescription granule takes the coastal glehnia root decoction pieces as raw materials to prepare the coastal glehnia root prescription granule through the technique procedures, such as twice water extraction, vacuum concentration, sponging drying, etc. 1g of the coastal glehnia root prescription granule is equal to 10-20g of crude drug. The quality of the coastal glehnia root decoction pieces and the coastal glehnia root decoction pieces and the coastal glehnia root prescription granule are identified by using IR fingerprint spectra. The coastal glehnia root prescription granule of the invention has complete and advanced production technique, specific and controllable quality control standard, scientific, advanced, rapid and operable detecting method related to the quality standard. A great number of experiments prove that the prepared soup of the coastal glehnia root prescription granule and the mixed simmered liquid of the classical prescription decoction pieces containing the coastal glehnia root have equal components, thus realizing the technique of full ingredient prescription granule and proving the reasonability of the technique of the invention; and in the invention, infrared spectroscopy technology is use for the quality control, rapidly solving a primary problem in macroscopic quality control of the traditional Chinese medicines-the identification of the truth of a traditional Chinese medicines.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule, a preparation method and a quality control method thereof, in particular to a northern Radix Ginseng formula granule, a preparation method and a quality control method thereof. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. At present, traditional Chinese medicine formula granules are mostly extracted with water, or extracted with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61K9/16A61J3/00G01N21/35G01N21/3563
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA
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