Astragalus dispensing granule as well as preparation method and quality control method

A technology of formula granules and astragalus is applied in the fields of traditional Chinese medicine formula granules and their preparation methods and quality control, and can solve problems such as difficulty in spectrum analysis.

Active Publication Date: 2009-07-08
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the spec

Method used

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  • Astragalus dispensing granule as well as preparation method and quality control method
  • Astragalus dispensing granule as well as preparation method and quality control method
  • Astragalus dispensing granule as well as preparation method and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Astragalus Formula Granules

[0037] Take 100kg of astragalus decoction pieces, add 800kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 800kg of water to the dregs, extract for 1.5 hours, that is, the second decoction; combine the two decoction liquids, and concentrate under reduced pressure to a relative density of 1.05-1.10 The concentrated solution is preheated at 45°C, the air inlet temperature is 180°C, the material pump speed is 550 rpm, the air outlet temperature is 80°C, and the air delivery temperature is 45°C and spray-dried to obtain Astragalus spray-dried powder; Add the auxiliary material dextrin of its own weight portion 0-5% in the powder; Astragalus spray-dried powder is 5MPa in the pressure of main pinch wheel, and the pressure of side pinch wheel is 0.5MPa, and the spindle speed is 400 rpm, and the feeding voltage is the condition of 120V Dry granulation to obtain 20-60 mesh astragalus formula gr...

Embodiment 2

[0038] Example 2: Astragalus Formula Granules

[0039] Take 100kg of astragalus decoction pieces, add 1000kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 600kg of water to the dregs, extract for 1 hour, that is, the second decoction; combine the two decoction liquids, and concentrate under reduced pressure to a relative density of 1.00-1.05 The concentrated solution is preheated at 50°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air delivery temperature is 50°C and spray-dried to obtain Astragalus spray-dried powder; Add 5-15% of its own weight of auxiliary material dextrin to the powder; dry granulation under the conditions of main pressure roller pressure 6MPa, side pressure roller pressure 0.4MPa, spindle speed 450 rpm, and feeding voltage 110V , to obtain 20-60 meshes of Astragalus formula granules, each gram of Astragalus formula granules is equivalent ...

Embodiment 3

[0041] Embodiment 3: Astragalus Formula Granules

[0042] Take 100kg of astragalus decoction pieces, add 1400kg of water, extract for 2.5 hours, that is, the first decoction; after the first decoction, add 1100kg of water to the dregs, extract for 2.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.10-1.15 The concentrated solution is preheated at 45°C, the air inlet temperature is 170°C, the material pump speed is 600 rpm, the outlet temperature is 75°C, and the air delivery temperature is 50°C and spray-dried to obtain Astragalus spray-dried powder; Add the lactose of its own weight portion 15-25% in the powder; Dry granulation under the condition that the main pressure wheel pressure is 4MPa, the side pressure wheel pressure is 0.4MPa, the spindle speed is 500 rev / min, and the feeding voltage is 130V, to obtain 20-60 mesh Astragalus formula granules, each gram of Astragalus formula granules is e...

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Abstract

The invention discloses a radix astragali formula particle and preparation and quality control methods thereof. The formula particle uses radix astragali decoction pieces as raw materials, and the decoction pieces are processed by the technological processes of twice water extraction, vaccum concentration, sponging drying and the like to gain the radix astragali formula particle; and one gram of radix astragali formula particle is equivalent to 3 to 5 grams of crude medicines, and the quality of the radix astragali decoction pieces and the radix astragali formula particle is respectively discriminated by the infrared fingerprint spectra. The radix astragali formula particle of the invention has the advantages of integrated and advanced production process, specific and controllable quality control standard and advanced and realizable process, and a test method related to the quality standard is scientific, advanced, fast and highly operable. Proved by a lot of experiments, the ingredient of a herbal decoction prepared by the radix astragali formula particle of the invention is equivalent to the ingredient of the mixed simmer liquid of the radix astragali contained classical formula, the full ingredient formula particle process is achieved, and the process of the invention is proved to be reasonable; and the invention applies the infrared spectroscopy technology to the quality control of the traditional Chinese medicines, thereby fast solving the principal problem of traditional Chinese medicine truth discrimination in the macroscopic quality control of the traditional Chinese medicines.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule and a preparation method and a quality control method thereof, in particular to an astragalus formula granule and a preparation method and a quality control method thereof. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. At present, traditional Chinese medicine formula granules are mostly extracted with water, or extracted with wate...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/16A61J3/00G01N21/35G01N21/3563
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA
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