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Composite disinfecting effervescent tablet and preparation method thereof

A technology of effervescent tablets and tablet auxiliary materials, which is applied in the direction of disinfectants, botany equipment and methods, biocides, etc., and can solve problems such as inability to use precision instruments and sharp instruments for disinfection, residues of toxic and side effects compounds, unfavorable human body and environment, etc. , to achieve the effect of enhancing antiviral effect, reducing dosage, and rapid bactericidal effect

Inactive Publication Date: 2009-08-05
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has a relatively definite bactericidal effect, but at the same time, there are certain toxic side effects and compound residues, which are not good for the human body and the environment
For example, peracetic acid is corrosive and can significantly damage marble, terrazzo and other materials, and it cannot be used for disinfection of precision instruments and sharp instruments.

Method used

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  • Composite disinfecting effervescent tablet and preparation method thereof
  • Composite disinfecting effervescent tablet and preparation method thereof
  • Composite disinfecting effervescent tablet and preparation method thereof

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preparation example Construction

[0037] The preparation method of the compound disinfectant effervescent tablet of the embodiment of the present invention is: under the environment that humidity is 20-45%, take polyvinylpyrrolidone, potassium bromide, antibacterial Chinese medicine extract, sodium carbonate, sodium bicarbonate and fully mix To obtain the first mixture, another hydantoin bromine-containing compound, adipic acid, sodium sulfate, and citric acid were mixed thoroughly to obtain the second mixture, and then the first mixture and the second mixture were evenly mixed, sieved and pressed into tablets. The humidity environment is preferably 25-40%, more preferably 35%. The concentration of the antibacterial Chinese medicine extract is 0.1-10 grams of the original drug in 1 g effervescent tablet, and the content of each component in the compound disinfection effervescent tablet is:

[0038] Hydantoin-like brominated compounds 0.1-30wt%

[0039] Polyvinylpyrrolidone 1-10wt%

[0040] Adipic acid 10-50w...

Embodiment 1

[0049] 1. Preparation of antibacterial traditional Chinese medicine extract

[0050] Banlangen is the dried root of Isatis indigotica Fort, a cruciferous plant. Take 1400g Radix Radix, add water and decoct twice, the first time is 2 hours, the second time is 1 hour, the decoction is filtered, the filtrates are combined, concentrated to a relative density of 1.20 (50°C), and ethanol is added to make the alcohol content reach 60 %, let stand to precipitate, take the supernatant, recover ethanol and freeze-dry to powder.

[0051] 2. Preparation of compound disinfectant effervescent tablet

[0052] Compound sterile effervescent tablets were prepared by dry compression method.

[0053] Formula: 200g of bromochlorohydantoin, 20g of polyvinylpyrrolidone, 200g of adipic acid, 72g of sodium carbonate, 25g of sodium bicarbonate, 200g of sodium sulfate, 148g of citric acid, 25g of bromochloroisocyanuric acid, 50g of the above-mentioned isatid root extract, bromine Potassium chloride 1...

Embodiment 2

[0058] Present embodiment is substantially the same as embodiment 1 preparation method, and method is as follows:

[0059] In an environment with a humidity of 25%, take 20g of polyvinylpyrrolidone, 15g of potassium bromide, 50g of Radix isatidis extract (powder) (containing 500g of crude drug), 60g of sodium carbonate, and 20g of sodium bicarbonate, and fully stir and mix the above ingredients; Separately take 230g of dibromohydantoin, 180g of adipic acid, 180g of sodium sulfate, and 120g of citric acid and mix thoroughly; stir and mix the two parts for 45 minutes, pass through a 20-mesh sieve, and press into tablets to obtain the product.

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Abstract

The invention provides hydantoin composite effervescent disinfectant tablets and a preparation method thereof. The components of the composite effervescent disinfectant tablets comprise hydantoin bromine-containing compounds, an antimicrobial traditional Chinese medicine extract and effervescent tablet accessories, wherein the concentration of the antimicrobial traditional Chinese medicine extract is that 1 gram of disinfectant tablets contains 0.1 to 10 grams of crude drugs; the content of the antimicrobial traditional Chinese medicine extract is 3 to 30 percent of the total weight; the content of the hydantoin bromine-containing compounds is 0.1 to 30 percent of the total weight; and the balance is the effervescent tablet accessories. The preparation method comprises the following steps that: in an environment at the humidity of between 20 and 45 percent, polyvinylpyrrolidone, potassium bromide, the antimicrobial traditional Chinese medicine extract, sodium carbonate and sodium bicarbonate are well mixed to give a first mixture; the hydantoin bromine-containing compounds, adipic acid, sodium sulfate and citric acid are well mixed to give a second mixture; and the first mixture and the second mixture are mixed well, sieved and tabletted. The composite effervescent disinfectant tablets have the advantages of low toxicity, environmental protection and high efficiency.

Description

technical field [0001] The invention relates to a disinfectant and a preparation method thereof, in particular to a compound disinfectant effervescent tablet mainly containing hydantoin compounds and supplemented by Chinese herbal medicine extracts and a preparation method thereof. Background technique [0002] Disinfectant refers to the preparation used to kill pathogenic microorganisms on the transmission medium to make them harmless. Its main function is to eliminate pathogenic microorganisms outside the human body, cut off the transmission route of infectious diseases, and achieve the purpose of controlling infectious diseases . [0003] There are many kinds of disinfectants, currently commonly used are mainly 2% glutaraldehyde disinfectant, sodium hypochlorite disinfectant, and peroxides such as quaternary ammonium salts, peracetic acid, and chlorine dioxide and other chlorine-containing preparations. [0004] Among them, 2% glutaraldehyde disinfectant is widely used i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N65/08A01N43/50A01N65/20A01N65/22A01N65/36A01N65/32A01N43/64A01P1/00A01N25/34
Inventor 裴渭静曾嘉明李荣先王乃利阎玺庆
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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