Kidney-nourishing and bone-tonifying chewable tablet and preparation method thereof

A technology of chewable tablets and oysters, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor drug compliance, long disintegration time, and inapplicability for the elderly, and achieve High bioavailability, broad application prospects, and the effect of improving the effect of calcium supplementation

Active Publication Date: 2009-08-05
刘艳 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage of Shengu powder is not accurate, it is inconvenient to carry, and the compliance of taking medicine is poor
Kidney bone capsules and kidney bone tablets have a long disintegration time and slow onset of action, and are not suitable for children and the elderly who have difficulty swallowing medicines

Method used

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  • Kidney-nourishing and bone-tonifying chewable tablet and preparation method thereof
  • Kidney-nourishing and bone-tonifying chewable tablet and preparation method thereof
  • Kidney-nourishing and bone-tonifying chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1 The preparation of kidney bone chewable tablet of the present invention

[0057] Oyster acetic acid extract was prepared by the method of Test Example 1.

[0058] Get oyster acetic acid extract 400g, xylitol 75g and aspartame 1.5g and mix evenly, add the dextrin slurry (concentration is 5wt%) of moistening amount to make soft material, cross 40 mesh sieves then, granulate, in Dry at 70-80°C, add 1g of talcum powder and mix evenly, spray 1g of lemon essence, mix evenly, and press into tablets to obtain.

[0059] The ambient humidity during the granulation and tabletting process is 55-67%.

Embodiment 2

[0060] Embodiment 2 The preparation of kidney bone chewable tablet of the present invention

[0061] Oyster acetic acid extract was prepared by the method of Test Example 1.

[0062] Get 600g of oyster acetic acid extract, 110g of xylitol and 3.5g of stevioside and mix them evenly; Dry at 80°C, add 2.3g of magnesium stearate and mix evenly, spray 3g of lemon essence, mix evenly, and press into tablets to obtain.

[0063] The ambient humidity during the granulation and tabletting process is 60-67%.

Embodiment 3

[0064] Example 3 Preparation of Kidney Bone Chewable Tablets of the present invention

[0065] Oyster acetic acid extract was prepared by the method of Test Example 1.

[0066] Get 500g of oyster acetic acid extract, 95g of xylitol and 3g of stevioside and mix evenly, add a moistening amount of dextrin slurry (concentration is 10wt%) to make a soft material, then pass through a 40-mesh sieve, granulate, and granulate at 70-80 Dry at ℃, add 2g of magnesium stearate and mix evenly, spray 1.5g of lemon essence, mix evenly, and press into tablets to obtain.

[0067] The ambient humidity during the granulation and tabletting process is 63-67%.

[0068] The Kidney bone chewable tablets prepared in Examples 1-3 were tested, and the results all conformed to the relevant regulations on chewable tablets in the Pharmacopoeia of the People's Republic of China (2005 edition).

[0069] Pharmacodynamic test Study on the anti-osteoporosis effect of the Shengu chewable tablet in rats induced...

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PUM

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Abstract

The invention relates to a kidney and bone chewable tablet and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The technical problem to be solved by the invention is to provide the kidney and bone chewable tablet which has good mouthfeel and is easy to take. The kidney and bone chewable tablet is prepared from the following raw materials in portion by weight: 1,200 to 1,700 portions of oyster acetic acid extract as calculated by oysters, 70 to 120 portions of filler, 1 to 6 portions of flavoring, 1 to 3 portions of flavoring agent and 1 to 3 portions of lubricant, wherein the filler is selected from at least one of lactose, sucrose, mannitol, D-sorbitol sorbitol, xylitol and starch; the flavoring is selected from at least one of aspartame, stevioside and albumen; the flavoring agent is selected from at least one of pennyroyal and flavoring lemon essence; and the lubricant is selected from at least one of magnesium stearate, talc powder and micropowder silica gel. The kidney and bone chewable tablet can be quickly disintegrated and dissolved after being chewed, is quick to take effect, has high bioavailability and good mouthfeel, is particularly suitable for children and the elderly which are difficult to take medicine, and has wide application prospect.

Description

technical field [0001] The invention relates to kidney bone chewable tablets and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Calcium accounts for about 2% in the human body, and the total calcium content in the adult body is about 1200g. In daily life, if the calcium intake is insufficient, the human body will experience physiological calcium overdraft, resulting in a decrease in blood calcium levels. Due to calcium deficiency, it may lead to osteoporosis, bone hyperplasia, rickets in children, tetany, hypertension, kidney stones, colon cancer, senile dementia and other diseases. Therefore, calcium-deficient people need to take calcium-containing preparations for calcium supplementation. At present, the active ingredients of calcium supplement preparations mainly include calcium carbonate, calcium lactate, calcium gluconate, active calcium, amino acid calcium, etc., but the calcium in most calcium sup...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/20A61K47/10A61P3/02A61K35/618
Inventor 李军刘艳张波
Owner 刘艳
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