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Compound dipeptide pharmaceutical formulations and preparation method thereof

A compound dipeptide and compound technology, applied in the field of medicine

Inactive Publication Date: 2009-08-12
大连紫萌科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the solubility and stability of glutamine and tyrosine, the clinical application of these two is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1. Preparation of Glycyl-L-Glutamine and Glycyl-L-Tyrosine Powder Injection (Aseptic Packing): Take 15.135Kg of Glycyl-L-Glutamine Sterile Powder and 1.725Kg of glycyl-L-tyrosine aseptic powder, mix well in a hundred-class clean room environment, and then aliquot into vials, each containing 15.135g of glycyl-L-glutamine aseptic powder And 1.725g of glycyl-L-tyrosine sterile powder.

Embodiment 2

[0013] Example 2. Preparation of glycyl-L-glutamine and glycyl-L-tyrosine freeze-dried powder injection: 15.135Kg glycyl-L-glutamine and 1.725Kg glycyl-L -Dissolve tyrosine with water for injection, prepare a 15% solution, add 0.1% (g / v) medicinal activated carbon, stir for 20 minutes for adsorption, decarburize and filter; finely filter through 0.45μm and 0.22μm microporous membranes Afterwards, it is divided into freeze-dried trays, the height of the liquid level of the drug solution should not exceed 3cm, and the product is freeze-dried to obtain a sterile powder. Dispense the above sterile powder into vials, each containing 15.135g of glycyl-L-glutamine sterile powder and 1.725g of glycyl-L-tyrosine sterile powder.

Embodiment 3

[0014] Example 3. Preparation of Glycyl-L-Glutamine and Glycyl-L-Tyrosine Injection:

[0015] Weigh 15.135Kg of glycyl-L-glutamine and 1.725Kg of glycyl-L-tyrosine and dissolve them with water for injection to prepare a 33.72% solution, add 0.1% (g / v) of medicinal activated carbon , Stir for 20 minutes for adsorption, decarburize and filter, measure the pH value, adjust the pH value between 5.0 and 6.0, add water for injection to the full amount; after fine filtration through 0.45μm and 0.22μm microporous membranes, light inspection and separate irrigation Pack it in a 50ml glass bottle, stopper, and autoclave at 115°C for 30min; light inspection; finished product inspection, packaged and stored, and the specification is 50ml: 16.86g dipeptide injection.

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PUM

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Abstract

The invention relates to a compound dipeptide medicine preparation and a preparation method thereof, belonging to the technical field of medicine. The compound dipeptide medicine preparation mainly consists of glycyl-L-glutamine and glycyl-L-tyrosine with the weight ratio of 100:5 to 100:25. The prepared clinical commonly used effective preparation formulation is liquid injection, freeze-dried powder injection or sterile subpackaging injection. The glycyl-L-glutamine enters the body and is quickly hydrolyzed into glycin and glutamine, thus playing the functions; and the glycyl-L- tyrosine enters the body and is quickly hydrolyzed into glycin and tyrosine, thus playing the functions. The compound dipeptide medicine preparation is a novel amino acid supplementary preparation by intravenous injection.

Description

Technical field: [0001] The invention relates to a compound dipeptide medicinal preparation and a preparation method thereof, and belongs to the technical field of medicine. The compound preparation is composed of glycyl-L-glutamine and glycyl-L-tyrosine in a certain proportion. The invention relates to the prescription ratio of this compound preparation and a preparation method thereof. Background technique: [0002] In the 1930s, Robert Elemn observed that amino acids in the form of protein hydrolysates can be safely used in humans. This is an important first step towards parenteral nutrition (PN). Total Parenteral Nutrition (TPN) was first reported by Dudric in 1968, that the intravenous supply of all nutrients required by the human body, including fat milk, amino acids, glucose, vitamins, electrolytes and trace elements, makes it impossible to take oral The long-term survival of ingested patients is a major achievement in modern nutritional therapy. Patients who need nutritio...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K9/08A61K9/19A61P3/02
Inventor 尚宝虎刘晓春
Owner 大连紫萌科技有限公司
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