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Formulations of acetylsalicylic acid or its derivatives in soft capsules, exhibiting high stability

A technology of acetylsalicylic acid and soft capsule preparation, applied in directions such as salicylic acid active ingredient, capsule delivery, non-central pain reliever, etc., can solve problems such as unsatisfactory stability

Active Publication Date: 2013-01-23
ALTERGON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] But, the stability of the soft capsule preparation of acetylsalicylic acid or its pharmaceutically acceptable derivative is not satisfactory yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation of Soft Gelatin Capsules Containing ASA, Omega-3 and Cyclodextrin in Both Filler and Shell

[0046] a) Prepare shell mixture

[0047] The composition, content and relative percentage of the formulation

[0048]Gelatin 150bloom 26.4Kg 33.0%

[0049] Propylene Glycol 1.6Kg 2.0%

[0050] Anid Thorpe (anidrisorb) 85 / 70 8.0Kg 10.0%

[0051] Dimethicone 1000 7.2Kg 9.0%

[0052] Hydroxypropyl-β-cyclodextrin 12.0Kg 15.0%

[0053] Pure water 24.8Kg 31.0%

[0054] 24.8 liters of purified water were added to 12.00 kg of hydroxypropyl-β-cyclodextrin (Kleptose hydroxypropyl -β-cyclodextrin) and kept stirring at 30°C for 15-60 minutes. When a clear solution is formed, add 1.6kg of propylene glycol, 7.2kg of dimethylsiloxane and 8.0kg of Anid Thorpe, stir again, and raise the temperature to 70°C; then add 26.4kg of gelatin and keep stirring 15-60 minutes.

[0055] Air bubbles were removed from the clot using a progressive vacuum pump until a vacuum between -0.8 a...

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PUM

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Abstract

The present invention relates to new formulations comprising acetylsalicylic acid or its derivatives an oil phase and a cyclodextria in soft capsules, characterized by a high stability.

Description

technical field [0001] The present invention relates to the field of preparation of new pharmaceutical preparations and relates to new preparations with high patient compliance and high stability. Background technique [0002] Acetylsalicylic acid (or aspirin) is a long known active ingredient traditionally as an anti-inflammatory / analgesic factor, and more recently as a platelet anti-aggregation factor (known as aspirin cardio). [0003] As for pharmaceutical preparations containing acetylsalicylic acid, a large number of preparations have been developed on a large scale during its use history of more than one hundred years. However, the known acetylsalicylic acid tends to be easily hydrolyzed, causing the problem of semi-spontaneous deterioration of active ingredients, which is difficult to control (see references 1, 2, 3 below). - [0004] Therefore, there is a need to develop more stable formulations with a constant acetylsalicylic acid content. [0005] Other compoun...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/60A61K47/40
CPCA61K31/60A61K9/4858A61K47/40A61K9/4816A61P29/00
Inventor 安杰尔·马特奥·埃查纳戈里亚毛里齐奥·马尔基奥里乔治·佐佩蒂
Owner ALTERGON