Metformin r-(+) lipoate as an antidiabetic agent for control of diabetic hyperglycemia and diabetic complications

Abstract

Described herein is a compound of Formula (I), which is the metformin salt of the naturally occurring endogenous biological compound, (R)-(+) a lipoic acid, pharmaceutical compositions containing the compound of Formula (I), and methods of treatment of diabetes or diabetic complications with the compound of Formula (I).

Description

Background of the invention

[0001] Diabetes is already widespread and according to the World Health Organization, the number of people with diabetes will increase dramatically by 2030. This is an ominous forecast, as addressing the long-term complications of diabetes, including nephropathy, neuropathy, retinopathy, and cardiovascular complications, will have serious implications for public health budgets. The hallmark of diabetes is chronically elevated blood glucose levels. Abnormally elevated glucose levels are also known to have adverse effects on glutathione levels in predominantly diabetic tissues. Additionally, hyperglycemic conditions involve increased oxidative stress and increased production of reactive oxygen species.

[0002] Despite the early discovery of insulin and its subsequent widespread use in the treatment of diabetes, and the later discovery and application of sulfonylureas and thiazolidinediones, such as troglitazone, rosiglitazone, or pioglitazone as or...

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