Method for heterogeneously catalyzed manufacture of carboxylic acid derivatives
A carboxylic acid derivative, heterogeneous catalysis technology, applied in methods of supporting/immobilizing microorganisms, biochemical equipment and methods, enzyme production/bioreactors, etc., can solve problems such as blocked voids, uneven flow, etc.
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Embodiment 1
[0071] Embodiment 1: test reactor structure:
[0072] An exemplary test reactor configuration is shown in Figure 5 middle. The loop reactor consisted of thermostatically controlled (8) reaction vessels (4, 5) having a length of 60 cm and a diameter of 2.5 cm. The reaction vessel was divided into two zones (4, 5) by a centrally mounted movable metal screen with a pore size of 50 μm. An additional metal screen divides the reaction vessel at the bottom and acts as a gas distributor. Thus, the heterogeneous catalyst remains in the lower part of the reaction vessel (4). Under the action of the peristaltic pump (2), the reaction mixture is pumped from the stirred storage vessel (1) above the gas sparger into the reaction vessel (4). At the same time, gas is introduced (3) into the reaction vessel from below in a controlled manner. The reaction mixture fills first the lower zone (4) and then the upper zone (5), holding the catalyst through a screen. When it reaches overflow,...
Embodiment 2
[0074] Example 2: Synthesis of myristyl myristate
[0075] 329 g of myristyl alcohol and 351 g of myristic acid were heated to 60° C. in a 1 L reservoir vessel and mixed by a magnetic stirrer (viscosity of the mixture at 60° C. was about 6 mPas). The lower part of the reaction vessel was initially charged with 2.7 g of Novozym 435 and the entire reaction vessel was heated to 60°C. The introduction of compressed air was controlled at 0.4 l / min, then the peristaltic pump was set at -20 ml / min and turned on. The reflux was heated to 60°C. The progress of the reaction was monitored for ~25h, and a conversion of 99.3% based on fatty acid was obtained.
[0076] Table 1: Conversion data for Example 2
[0077] time [min] Conversion rates[%] 0 0 30 25.8％ 60 46.9％ 124 74.6％ 169 85.7％ 223 92.6％ 300 96.5％ 346 97.4％ 1442 99.3％
Embodiment 3
[0078] Embodiment 3: the reuse of catalyst
[0079] Similar to Example 2, several reactions for the synthesis of myristyl myristate were carried out, using the enzyme catalyst repeatedly without intermediate purification, and the conversion after 1 and 24 hours was determined. Do 10 repetitions.
[0080] Table 2: Conversion data for Example 3
[0081] repeat Conversion rate after 1h Conversion rate after 24h 1 46.9％ 99.3％ 2 45.3％ 99.6％ 3 46.2％ 99.3％ 4 44.7％ 99.5％ 5 47.1％ 99.1％ 6 46.9％ 99.2％ 7 44.7％ 99.0％ 8 47.4％ 98.9％ 9 45.2％ 99.2％ 10 44.3％ 99.0％
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