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Glycyrrhizin derivatives and preparation and use thereof

A technology of drugs and compounds, applied in the field of pharmaceutical compositions containing them, can solve problems such as poor therapeutic effect

Inactive Publication Date: 2009-11-04
吕秋军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therapeutic drugs include non-steroidal anti-inflammatory drugs and immunosuppressant methotrexate, etc., and the treatment effect is not good

Method used

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  • Glycyrrhizin derivatives and preparation and use thereof
  • Glycyrrhizin derivatives and preparation and use thereof
  • Glycyrrhizin derivatives and preparation and use thereof

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Embodiment Construction

[0069] All the documents cited in the present invention are incorporated herein by reference in their entirety, and if the meaning expressed in these documents is inconsistent with the present invention, the expression of the present invention shall prevail. In addition, various terms and phrases used in the present invention have common meanings known to those skilled in the art. Even so, the present invention still hopes to make a more detailed description and explanation of these terms and phrases here. The terms and phrases mentioned are as follows: If there is any inconsistency with the known meaning, the meaning expressed in the present invention shall prevail.

[0070] The term "halogen", "Hal" or "halo" refers to fluorine, chlorine, bromine, and iodine.

[0071] The terms "alkyl", "alkenyl" and "alkynyl" used in the present invention have the common meanings known in the art, which are straight-chain or branched hydrocarbon groups, such as but not limited to methyl, et...

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PUM

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Abstract

The invention relates to Glycyrrhizin derivatives and preparation and use thereof, in particular to a compound in formula I: wherein, n is 0 or 1; R1 is C3-8 cycloalkyl; and R2 is H, as well as isomers, racemes, antimers, diastereomers, antimer concentrates, solvates, prodrugs and esters thereof. The invention further relates to a preparation method of the compound in the formula I, a pharmaceutical composition containing the compound in the formula I, and use of the compound in the formula I for preparing drugs for treating and / or preventing cerebral ischemic diseases, neurodegenerative diseases and inflammatory diseases. The compound in the formula I can be used for effectively treating and / or preventing the diseases described in the invention.

Description

technical field [0001] The present invention relates to a class of liquiritigenin derivatives, a preparation method thereof, and a pharmaceutical composition containing them. The liquiritigenin derivatives of the present invention can be effectively used for the treatment and / or prevention of cerebral ischemic diseases, neurodegenerative diseases, and inflammatory diseases. Background technique [0002] Licorice contains a large number of flavonoids, including Liquiritigenin, namely 4', 7-Dihydroxyflavanone (Chinese name: 4', 7-dihydroxy-flavanone), also known as 7-Hydroxy-2-(4 -hydroxy-phenyl)-chroman-4-one (Chinese name: 7-hydroxy-2-(4-hydroxy-phenyl)-chroman-4-one), its structural formula is as follows: [0003] [0004] According to literature reports, liquiritigenin has anti-acute liver injury (Chem Biol Interact, 2006, 161(2): 125-138), inhibits xanthine oxidase (Cell mol Life Sci, 2000, 57(3): 500-505), etc. active. In the previous patent application, the invent...

Claims

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Application Information

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IPC IPC(8): C07D311/32A61K31/352A61P9/10A61P25/28A61P25/16A61P29/00A61P1/04A61P19/04A61P25/00A61P43/00
CPCC07D311/32A61P1/04A61P9/10A61P19/04A61P25/00A61P25/16A61P25/28A61P29/00A61P43/00
Inventor 吕秋军
Owner 吕秋军
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