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Application of imatinib mesylate in preparing drugs used for building congenital cataract animal model

A technology for imatinib mesylate and congenital cataract, which is applied in a new application field of medicine, can solve problems such as imatinib mesylate that have not been seen, and achieves the effects of short cycle, simple method and low cost

Inactive Publication Date: 2011-10-05
ARMY MEDICAL UNIV
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Problems solved by technology

But so far, there are no relevant reports on the application of imatinib mesylate in the preparation of drugs for the establishment of congenital cataract models

Method used

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  • Application of imatinib mesylate in preparing drugs used for building congenital cataract animal model
  • Application of imatinib mesylate in preparing drugs used for building congenital cataract animal model
  • Application of imatinib mesylate in preparing drugs used for building congenital cataract animal model

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Embodiment Construction

[0016] The application and effect of imatinib mesylate in the preparation of drugs for establishing animal models of congenital cataract will be described in detail below with reference to the accompanying drawings.

[0017] 1. Experimental animals and materials

[0018] Clean-grade BABL / c mice on the 8th day of birth were purchased from the Animal Center of the Third Military Medical University of the Chinese People's Liberation Army; imatinib mesylate capsules were purchased from Novartis Pharmaceuticals Co., Ltd., Switzerland. Dissolve in distilled water to make a solution with a concentration of 100 mg / mL, and store at 4°C for later use.

[0019] 2. Experimental method

[0020] The clean-grade BABL / c mice on the 8th day of birth were randomly divided into two groups: the experimental group and the control group, and the experimental group was given a concentration of Imatinib mesylate solution of 100 mg / mL was administered continuously for 3 days; the control group was g...

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Abstract

The invention discloses an application of imatinib mesylate in preparing drugs used for building congenital cataract animal model. Applying the imatinib mesylate to build the congenital cataract animal model has the advantages of simple method, short period, low cost, high film forming rate, good reproduction quality and the like. The obtained animal model can better simulate the congenital cataract of baby lens caused by receptor signal access barrier of platelet-derived growth factors due to various reasons during the growing process before or after birth, and is applicable to studies on various aspects of the nosogenesis of the congenital cataract, therapeutic drug screening, mechanism of action, and the like.

Description

technical field [0001] The present invention relates to a new application of medicine, in particular to the application of imatinib mesylate in the preparation of medicine for establishing animal models of congenital cataract. Background technique [0002] Congenital cataract is a common eye disease in children. Partial or total clouding of the lens that occurs in the first year of life is called congenital cataract. Congenital cataract is also called infantile cataract because the factors that cause the clouding of the lens have existed at birth, but the cataract has not yet appeared, and the clouding of the lens occurs within one year old. [0003] Congenital cataract can seriously affect the development of vision, and is one of the main causes of amblyopia and blindness in children. It is more harmful than senile cataract. Its etiology is complex, in addition to heredity, fetal viral infection, malnutrition and metabolic disorders, etc., about 1 / 3 of the children have u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/506A61K49/00A01K67/027
Inventor 梅峰郭晟肖岚韩鹃李世峰
Owner ARMY MEDICAL UNIV
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