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Preparation method for nano hydroxyapatite with directionally arranged granules

A technology of nano-hydroxyapatite and directional alignment, which is applied in the direction of nanostructure manufacturing, nanotechnology, nanotechnology, etc., can solve the problems of not showing good binding force and compatibility of polymer materials, limiting applications, etc., and achieve good The effects of biocompatibility and physiological safety, wide application, and easy promotion and application

Inactive Publication Date: 2012-03-28
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The Chinese invention patent application number is 200610055171.X discloses "a method for preparing spherical hydroxyapatite nanocrystals", using polyvinylpyrrolidone (PVP) as a template, and using the principle of biomineralization to synthesize spherical hydroxyapatite nanocrystals, However, only spherical nanocrystals of different sizes were obtained, and it did not involve the directional arrangement of particles, nor did it involve the control of the degree of crystallization of hydroxyapatite
The spherical hydroxyapatite nanocrystals described in this patent do not show good binding force and compatibility with polymer materials, which also limits its application in some specific biological fields

Method used

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  • Preparation method for nano hydroxyapatite with directionally arranged granules
  • Preparation method for nano hydroxyapatite with directionally arranged granules
  • Preparation method for nano hydroxyapatite with directionally arranged granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method of nano-hydroxyapatite with oriented particle arrangement comprises the following steps and process conditions thereof:

[0036] Step 1: Preparation of nano-hydroxyapatite sol

[0037] (1) Use polyvinylpyrrolidone (PVP K15) as template agent, dispersant and modifier at the same time;

[0038] (2) Use deionized water to prepare a solution containing 0.01mol / L of calcium nitrate and 0.006mol / L of diammonium hydrogen phosphate, and then add 0.1g of PVP K15 to the above-mentioned calcium nitrate solution to fully dissolve;

[0039] (3) Using a high-speed disperser at 100 rpm, under the condition that the pH value of the ammonia water control system is 10.6, the materials in the above (1) and (2) are fully mixed to form a nano-hydroxyapatite sol, and the nano-hydroxyapatite sol is made. The molar ratio of calcium to phosphorus in the hydroxyapatite sol system reaches 1.6:1, and the content of polyvinylpyrrolidone is 0.01% by mass percentage;

[0040] S...

Embodiment 2

[0043] A preparation method of nano-hydroxyapatite with oriented particle arrangement comprises the following steps and process conditions thereof:

[0044] Step 1: Preparation of nano-hydroxyapatite sol

[0045] (1) Use polyvinylpyrrolidone (PVP K30) as template agent, dispersant and modifier at the same time;

[0046] (2) Use the PVP K30 aqueous solution of mass percent 0.5% to prepare the solution containing calcium nitrate 0.1mol / L, disodium hydrogen phosphate 0.06mol / L;

[0047] (3) adopting a high-speed disperser of 1000 rpm, under the condition that the pH value of the sodium hydroxide control system is 11, the materials of the above-mentioned (1), (2) are fully mixed to form nano-hydroxyapatite sol, Make the molar ratio of calcium and phosphorus in the nano-hydroxyapatite sol system reach 1.65:1, and the content of polyvinylpyrrolidone by mass percentage is 0.5%;

[0048] Step 2: Post-treatment of nano-hydroxyapatite sol

[0049] Move the above-mentioned hydroxyapat...

Embodiment 3

[0051] A preparation method of nano-hydroxyapatite with oriented particle arrangement comprises the following steps and process conditions thereof:

[0052] Step 1: Preparation of nano-hydroxyapatite sol

[0053] (1) Use polyvinylpyrrolidone (PVP K60) as template agent, dispersant and modifier at the same time;

[0054] (2) use the PVP K60 aqueous solution of 5% by mass percentage to prepare the solution containing calcium nitrate 0.5mol / L, dipotassium hydrogen phosphate 0.3mol / L;

[0055] (3) adopt the high-speed disperser of 2000 revs / min, under the condition that potassium hydroxide control system pH value is 11.5, the material of above-mentioned (1), (2) is fully mixed, forms nano-hydroxyapatite sol, makes The molar ratio of calcium to phosphorus in the nano-hydroxyapatite sol system reaches 1.67:1, and the polyvinylpyrrolidone content is 5% by mass percentage;

[0056] Step 2: Post-treatment of nano-hydroxyapatite sol

[0057] Move the above-mentioned hydroxyapatite so...

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Abstract

The invention discloses a preparation method for the nano hydroxyapatite with directionally arranged granules. The method comprises: adopting the high speed dispersion machine, completely mixing the template agent, the dispersant, and the modifying agent of polyvinyl pyrrolidon, 0.01-3 mol / L of calcium salt, 0.006-1.8 mol / L of phosphate solution or phosphoric acid in a alkali liquor control system, forming a sol system, wherein the calcium phosphorus molar ratio is 1.6-1.7 : 1 and the polyvinyl pyrrolidon mass percent is 0.01-50%; aging, washing, drying to obtain the nano hydroxyapatite with directionally arranged granules. The hydroxyapatite has controllable crystallization degree, high disperse, directional structure and stable bonding with the high molecule material.

Description

technical field [0001] The invention relates to the technical field of artificial bone repair materials, and specifically refers to a preparation method of a kind of nano-apatite whose particles are oriented to arrange medroxyl using a polymer surfactant as a template, a dispersant and a modifying agent. Background technique [0002] Due to its fine size and large specific surface area, nano-hydroxyapatite has different physical and chemical properties from ordinary hydroxyapatite, such as higher solubility, greater surface energy, and better biological activity, but the particle size is not easy to control , are easy to agglomerate and have weak interfacial bonding with polymers, thus adversely affecting biological applications. So far, a lot of research progress has been made in the field of biomaterials at home and abroad. For example: Ye Jiandong, Xiao Feng, Wang Xiupeng, etc. Anti-agglomeration effect of sodium lauryl sulfate in the synthesis of hydroxyapatite powder b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82B3/00A61L27/12A61L27/16
Inventor 宁成云王迎军尹兆益郑华德张德贵
Owner SOUTH CHINA UNIV OF TECH