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Method for preparing crystallization controllable nano hydroxyapatite powder

A technology of nano-hydroxyapatite and hydroxyapatite, which is applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., and can solve the problems of powder dispersibility that have not been reported.

Inactive Publication Date: 2009-10-21
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Such patents do not report on the dispersibility of the powder

Method used

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  • Method for preparing crystallization controllable nano hydroxyapatite powder
  • Method for preparing crystallization controllable nano hydroxyapatite powder
  • Method for preparing crystallization controllable nano hydroxyapatite powder

Examples

Experimental program
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Embodiment 1

[0018] Step 1: Preparation of calcium phosphorus bioglass additive

[0019] Take by weighing 28.39g phosphorus pentoxide and measure 400ml absolute ethanol, P 2 o 5 Slowly added to the ethanol solution. Since the non-oxidized phosphorus reacts violently with ethanol and releases a large amount of heat, the P 2 o 5 When adding ethanol, be sure to add it slowly in small amounts. Stir for 1 h after mixing to form a stable and transparent phosphorus-based sol with a concentration of 0.5 mol / l. Then, weigh 1.89g sodium methoxide, 59.04g calcium nitrate tetrahydrate and 3.15g strontium nitrate, measure 500ml ethylene glycol solution, mix and stir for 1h to form a 0.5mol / l transparent sol. Then the sol containing Ca, Sr and Na was slowly added dropwise to the phosphorus-based sol, mixed and stirred for half an hour, ultrasonically dispersed for 10 minutes, and finally a transparent and uniform calcium-phosphorus glass sol was obtained. Seal the obtained mixed sol and keep the t...

Embodiment 2

[0023] Step 1: Preparation of calcium phosphorus bioglass additive

[0024] Take by weighing 13.93g phosphorus pentoxide and measure 270ml absolute ethanol, P 2 o5 Slowly added to the ethanol solution. In order to avoid the violent reaction between non-oxidized phosphorus and ethanol, which will generate more heat and cause sputtering of the solution, the P 2 o 5 Add to ethanol. Stir for 1 h after mixing to form a stable and transparent phosphorus-based sol with a concentration of 0.5 mol / l. Then, weigh 1.26g of sodium methoxide, 41.19g of calcium nitrate tetrahydrate and 2.10g of strontium nitrate, measure 335ml of ethylene glycol solution, mix and stir for 1h to form a 0.5mol / l transparent sol. The sol containing Ca, Sr and Na was slowly added dropwise to the phosphorus-based sol, mixed and stirred for half an hour, and ultrasonically dispersed for 10 minutes to finally obtain a transparent and uniform calcium-phosphorus glass sol. Seal the obtained mixed sol, and keep ...

Embodiment 3

[0028] Step 1: Preparation of calcium phosphorus bioglass additive

[0029] Take by weighing 56.37g phosphorus pentoxide and measure 500ml absolute ethanol, P 2 o 5 Slowly added to the ethanol solution. Since the non-oxidized phosphorus reacts violently with ethanol and releases a large amount of heat, the P 2 o 5 When adding ethanol, be sure to add it slowly in small amounts. After mixing, stir for 1.5h to form a stable and transparent phosphorus-based sol with a concentration of 0.8mol / l. Then, weigh 3.02g sodium methoxide, 8.06g calcium nitrate tetrahydrate and 5.04g strontium nitrate, measure 500ml ethylene glycol solution, mix and stir for 1h to form a 0.8mol / l transparent sol. Then the sol containing Ca, Sr and Na was slowly added dropwise to the phosphorus-based sol, mixed and stirred for half an hour, ultrasonically dispersed for 10 minutes, and finally a transparent and uniform calcium-phosphorus glass sol was obtained. Seal the obtained mixed sol, and keep the ...

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Abstract

The invention discloses a preparation method of nano-hydroxyapatite powder with controllable crystallization degree. The method comprises the following steps: P2O5 is added in absolute ethanol to prepare phosphorus-based sol; calcium nitrate tetrahydrate, strontium nitrate and sodium methylate are dissolved in ethylene glycol solution to prepare component sol, according to CaO:P2O5:SrO: Add the component sol dropwise to the phosphorus-based sol at the molar ratio of Na2O to obtain a mixed sol, dry the mixed sol, pre-calcine, melt, quench, grind, and sieve to obtain a calcium-phosphorus bioglass additive; according to Ca / P mole Add the P2O5 solution dropwise to the Ca(NO3)2·4H2O solution at a ratio of 1.67, and add the calcium-phosphorus bioglass additive according to the mass ratio, then heat and stir to obtain a transparent solution, which is dried and calcined to obtain a particle size of 10 The HAp powder with a low crystallinity of ~30nm is continuously calcined to obtain a nanometer HAp powder with good crystallinity. The nanometer HAp powder prepared by the invention has low heat treatment temperature, high purity, controllable crystallinity and good dispersibility, and can be used for bone tissue defect, repair, drug carrier and the like.

Description

technical field [0001] The invention relates to a method for preparing nano-hydroxyapatite powder with controllable crystallization degree, and belongs to the technical field of biological material preparation. Background technique [0002] Hydroxyapatite (HAp) is the main inorganic component of human and animal bones and teeth. In bone, HAp accounts for about 60%. It is a needle with a length of 200-400 μm and a thickness of 15-30 μm. Collagen fibers are regularly arranged around it. Because of its good bioactivity and biocompatibility, it can form a close combination with the soft and hard tissues of the human body in a short period of time after being implanted into the human body, so it has become a widely used implant. Bone substitutes. Medical research shows that nano-hydroxyapatite particles (or ultrafine HAp powder) have stronger biological activity than ordinary hydroxyapatite. When the particles are finer, the torsional modulus, tensile modulus and tensile modulus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32
Inventor 蔡舒张文娟许国华赵玲革张喆
Owner TIANJIN UNIV