Compound neomycin sulphate solution and preparation method thereof

A technology of neomycin sulfate and colistin sulfate, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. It can reduce the frequency of medication, inhibit glandular secretion, and avoid bacterial drug resistance.

Inactive Publication Date: 2010-01-20
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the disease tends to be mixed and complicated. The pathogenic bacteria are resident bacteria in the body and have serious drug resistance. Nowadays, single drugs such as neomycin sulfate and colistin sulfate often make the treatment effect less effective due to their drug resistance. Poor, bring great loss to farmers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Add 10 kg of 95% ethanol to 2 kg of neomycin sulfate and 15 kg of colistin sulfate, stir and mix to infiltrate neomycin sulfate and colistin sulfate, after infiltration, add 70 L of purified water, and stir to make neomycin sulfate Mycin and colistin sulfate were fully dissolved.

[0021] (2) Take 2 L of purified water and dissolve 0.01 kg of scopolamine methyl bromide.

[0022] (3) merging the prepared solution of step (1) and step (2), replenishing purified water to 100L, and adjusting the pH value with a sodium hydroxide solution of 40% or a hydrochloric acid solution of 10% with a mass percentage concentration to 4.0~5.0 to get the compound neomycin sulfate solution of the present invention.

Embodiment 2

[0024] (1) Add 10 kg of 95% ethanol to 15 kg of neomycin sulfate and 3 kg of colistin sulfate, stir and mix to infiltrate neomycin sulfate and colistin sulfate, after infiltration, add 70 L of purified water, and stir to make neomycin sulfate Mycin and colistin sulfate were fully dissolved.

[0025] (2) Get 2L of purified water and dissolve scopolamine methyl bromide 0.05kg;

[0026] (3) merging the prepared solution of step (1) and step (2), replenishing purified water to 100L, and adjusting the pH value with a sodium hydroxide solution of 40% or a hydrochloric acid solution of 10% with a mass percentage concentration to 4.0~5.0 to get the compound neomycin sulfate solution of the present invention.

Embodiment 3

[0028] (1) Add 10 kg of 95% ethanol to 5 kg of neomycin sulfate and 13 kg of colistin sulfate, stir and mix to infiltrate neomycin sulfate and colistin sulfate. After infiltration, add 70 L of purified water and stir to make neomycin sulfate Mycin and colistin sulfate were fully dissolved.

[0029] (2) Take 2 L of purified water and dissolve 0.015 kg of scopolamine methyl bromide.

[0030] (3) merging the prepared solution of step (1) and step (2), replenishing purified water to 100L, and adjusting the pH value with a sodium hydroxide solution of 40% or a hydrochloric acid solution of 10% with a mass percentage concentration to 4.0~5.0 to get the compound neomycin sulfate solution of the present invention.

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PUM

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Abstract

The invention discloses a compound neomycin sulphate solution and a preparation method thereof. The invention aims to provide a compound neomycin sulphate solution which has obvious effect on treating gastrointestinal infection of birds, treats symptoms and a root and reduces the medicine application frequency and a preparation method thereof. 100 L of solution comprises 2-15 kg of neomycin sulphate, 3-15 kg of colistin sulphate, 0.01-0.05 kg of scopolamine methobromide, 10 kg of alcohol with concentration of 95 percent and the balance of purified water. The invention adopts the neomycin sulphate and the colistin sulphate as antibacterial components, has double effects, can effectively reduce the medicine resistant rate of bacteria and has effect on common Gram negative bacteria causing intestinal infection; and the scopolamine methobromide inhibits glandular secretion, dries intestinal contents and lightens a dehydration symptom so as to have a rapid therapeutic effect.

Description

technical field [0001] The invention relates to a compound neomycin sulfate solution for treating poultry digestive tract bacterial infection and a preparation method thereof. Background technique [0002] Bacterial infection of poultry digestive tract is a common disease in poultry. Sick poultry manifests as diarrhea and dysentery. It is mainly caused by single or mixed infection of Gram-negative bacteria such as Escherichia coli and Salmonella. Diarrhea, dysentery, white, gray, yellow or yellow-green loose stools, some of which are water samples, severe dehydration of sick birds, and high mortality. [0003] At present, the disease tends to be mixed and complicated. The pathogenic bacteria are resident bacteria in the body and have serious drug resistance. Nowadays, single drugs such as neomycin sulfate and colistin sulfate often make the treatment effect less effective due to their drug resistance. Not good, bring very big loss to farmer. Contents of the invention [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K9/08A61K47/10A61P31/04A61P1/00A61K31/7036A61K31/46
Inventor 徐克福
Owner TIANJIN SHENGJI GRP CO LTD
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