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Oral instant membrane of risperidone and preparation method thereof

An oral instant film, risperidone technology, which is applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc. problem, to achieve the effect of good compliance

Inactive Publication Date: 2010-12-08
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral solution requires a special quantitative cup, which is inconvenient to carry, which affects the wide application of risperidone oral preparations

Method used

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  • Oral instant membrane of risperidone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Component Weight (g)

[0037] Risperidone 10

[0038] Hydroxypropyl methylcellulose (5 centipoise) 500

[0039] 70% ethanol 1000

[0040] Specific operation process: Disperse risperidone in 70% ethanol under stirring, sonicate until dissolved, add hydroxypropyl methylcellulose (5 centipoise) to the above solution under stirring, and fully disperse to obtain a gel. After degassing, apply the above-mentioned risperidone gel evenly on a flat plate, blow air, heat and dry at a heating temperature of 60°C, and cut to obtain the risperidone oral instant film.

Embodiment 2

[0042] Component Weight (g)

[0043] Risperidone 10

[0044] Hydroxypropyl methylcellulose (20 centipoise) 500

[0045] 70% ethanol 1000

[0046] Specific operation process: Disperse risperidone in 70% ethanol under stirring, sonicate until dissolved, add hydroxypropyl methylcellulose (20 centipoise) to the above solution under stirring, and fully disperse to obtain a gel. After degassing, apply the above-mentioned risperidone gel evenly on a flat plate, blow air, heat and dry at a heating temperature of 60°C, and cut to obtain the risperidone oral instant film.

Embodiment 3

[0048] Component Weight (g)

[0049] Risperidone 10

[0050] Hydroxypropyl methylcellulose (50 centipoise) 500

[0051] 70% ethanol 1000

[0052] Specific operation process: Disperse risperidone in 70% ethanol under stirring, ultrasonically treat until dissolved, add hydroxypropyl methylcellulose (50 centipoise) to the above solution under stirring, and fully disperse to obtain a gel. After degassing, apply the above-mentioned risperidone gel evenly on a flat plate, blow air, heat and dry at a heating temperature of 60°C, and cut to obtain the risperidone oral instant film.

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Abstract

The invention relates to an oral instant membrane of risperidone and a preparation method thereof, thereby being used for improving the using performance of the risperidone. The technical scheme is as follows: the instant membrane comprises 2-60 parts by weight of risperidone, 25-98 parts by weight of water-soluble pharmaceutical polymer excipients, additives and 0.1-25 parts by weight of water. The oral instant membrane solves the problems that the existing risperidone is clinically difficult to swallow, is not applicable to children and elderly patients for administration and can not be conveniently taken under the situation of having no water. The oral instant membrane can be dissolved on the tongue, the hidden trouble of choking can not be happened no matter how young a baby is, the active ingredients can be absorbed sublingually and absorbed by buccal mucosa, and the onset of action is more rapid in comparison with orally disintegrating tablets. In addition, the oral instant membrane has good compliance, thereby being particularly suitable for elderly people, children and patients with difficult swallowing.

Description

technical field [0001] The invention relates to an oral instant film of medicine and a preparation method thereof, in particular to an oral instant film of risperidone, which belongs to the technical field of medicine. Background technique [0002] Risperidone (Resperidone, RIS), is a benzisoxazole derivative, its chemical name is 3-[2-[4-(6-fluoro-1,-2-benzisoxazol-3-yl) )-1-piperidinyl] ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one, the structural formula is as follows: [0003] [0004] Risperidone is a new type of atypical antipsychotic drug developed by the Belgian Janssen Pharmaceutical Company. It is suitable for the treatment of acute and chronic schizophrenia and other obvious positive symptoms (such as hallucinations, delusions, disordered thinking, hostility and suspicion) and obvious negative symptoms (such as unresponsiveness, emotional apathy, social apathy and Speechlessness) and may also be used to reduce the affective symptoms assoc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/519A61K47/38A61P25/18
Inventor 高子彬李会勇王素敏谢英花许淑婷耿建宁曹晓颖
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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