Quality control method of ginkgolide injection

A quality control method and ginkgolide technology, which are used in the quality control of ginkgolide injection and the quality control of traditional Chinese medicine preparations
CN101647829AActive Publication Date: 2010-02-17JIANGSU KANION PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU KANION PHARMA CO LTD
Publication Date
2010-02-17

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Abstract

The invention relates to a quality control method of injection, in particular to a quality control method of ginkgolide injection. The invention provides a method for controlling the quality of the ginkgolide injection by adopting high performance liquid chromatography. The method can control the quality of the ginkgolide injection by adopting one or more of a content determination method, a limittest method of dissociation ginkgolide and a chromatographic fingerprint method. The quality control method provided by the invention has the advantages of having high precision, stability and repeatability, and achieving the aim of effectively controlling the quality of the ginkgolide injection in an all-round way.
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Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine analysis, and relates to a quality control method of traditional Chinese medicine preparations, in particular to a quality control method of ginkgolide injection. The quality control method includes a content determination method, a limit inspection method and a fingerprint spectrum determination method. technical background

[0002] Ginkgolides are a group of terpenoids with strong biological activity contained in Ginkgo Leaf. The isolated ones include ginkgolides A, B, C, J, M, K, L and Bilobalides have been found to be strong antagonists of the vascular activating factor (PAF) and have good application prospects. BN52063 (Ginkgolide Mixture) and BN52021 (Ginkgolide B) have entered the clinical trial stage abroad.

[0003] Ginkgolide injection is an injection made from total ginkgolides, the main component of which is ginkgolide A (C 20 h 24 o 9 ), ginkgolide B (C 20 h 24 o 10 ...

Claims

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