Segmentation method of cell nucleolus and cell membrane based on mixed contour model

A contour model, cell nucleolus technology, applied in the field of biological cell microscopic image segmentation, can solve the problems of poor segmentation effect and low precision

Active Publication Date: 2010-03-03
山东盛世共青茶业有限公司
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Problems solved by technology

[0006] In order to overcome the shortcomings of low precision and poor segmentation effect of the existing cell image segmentation method, the present ...

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  • Segmentation method of cell nucleolus and cell membrane based on mixed contour model
  • Segmentation method of cell nucleolus and cell membrane based on mixed contour model
  • Segmentation method of cell nucleolus and cell membrane based on mixed contour model

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Embodiment Construction

[0039] The present invention will be further described below in conjunction with the accompanying drawings.

[0040] A method for segmenting cell nucleoli and cell membranes based on a mixed contour model, the segment method comprising the following steps:

[0041] 1), the cell image to be segmented according to the mixed contour model to establish an energy function, the form is as follows:

[0042] E. E (φ, c 1 , c 2 , f 1 , f 2 ) = E M (φ, c 1 , c 2 , f 1 , f 2 )+P(φ)+L(φ) (11);

[0043] Among them, E M (φ, c 1 , c 2 , f 1 , f 2 ) represents the energy function based on the regional model and the local binary fitting model, and its calculation formula is:

[0044] E. M (φ, c 1 , c 2 , f 1 , f 2)=(1-λ g )E LBF (φ, f 1 , f 2 )

[0045] +λ g (x, y)E G (φ, c 1 , c 2 ) (7);

[0046] where λ g is the strategy weight parameter, E LBF (φ, f 1 , f 2 ) as defined in formula (6), E G (φ, c 1 , c 2 ) as defined in formula (5):

[0047] E. G (φ, c...

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Abstract

The invention relates to a segmentation method of cell nucleolus and cell membrane based on a mixed contour model. The method comprises the following steps: 1) according to the mixed contour model, establishing an energy function of a cell image to be segmented, the form of which is: such as E<E>(Phi, c1, c2, f1, f2)=E<M>(Phi, c1, c2, f1, f2)+P(Phi)+L(Phi); and 2) constructing and using a steepestdescent method to minimize the formula, calculating the border of the cell nucleolus and cell membrane of the cells by utilizing the level set function Phi being equal to zero through an iterative approach of discretization of partial differential equations. The invention provides a segmentation method of cell nucleolus and cell membrane based on the mixed contour model, which has high precisionand excellent segmentation effect.

Description

technical field [0001] The invention relates to image processing, biomedicine, computer vision, computing methods, especially the segmentation method of microscopic images of biological cells. Background technique [0002] Over the years, biological inventions and their translation into clinically applicable treatments have advanced rapidly. Pathologists use pathological images of patient tissue sections and examine them under a microscope. When examining such images, pathologists often use tissue images to detect changes in cellular structure and the ratio of nucleoli to cytoplasm to assess the extent of disease. It is particularly important to automatically detect the outline of cells and their nucleoli. [0003] In the field of cell image processing, there have been a lot of research results. But at the same time there are some challenges in these studies. Noise pollution is one of the most frequently occurring problems. This kind of problem arises from the dyeing pr...

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Application Information

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IPC IPC(8): G06T5/00
Inventor 陈胜勇陈敏姚春燕管秋赵明珠
Owner 山东盛世共青茶业有限公司
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