Method for preparing lenalidomide
A technology of reflux temperature and reaction temperature, applied in the direction of organic chemistry, etc., can solve the problems of long steps, difficult industrialization, high risk, etc., and achieve the effect of low production cost, short reaction steps, and no three wastes
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[0035] (1) Preparation of methyl 2-methyl-3-nitrobenzoate
[0036] 18.1g (0.1mol) of 2-methyl-3-nitrobenzoic acid, dissolved in 200ml of anhydrous methanol, keep below 0℃, add 11.9g (0.1mol) of thionyl chloride dropwise, after dripping, heat to reflux for 1 hour . The methanol was evaporated to dryness, poured into ice water, the pH was adjusted to 7-9, stirred for 2-3 small tests, a yellow solid was precipitated, filtered, and dried to obtain 18 g of product with a yield of 92.3%.
[0037] 1 H NMR (300MHz, CDCl3) δ: 2.6 (s, 3H), 3.95 (s, 3H), 7.35 (m, 1H), 7.90 (m, 2H)
[0038] (2) Preparation of methyl 2-chloromethyl-3-nitrobenzoate
[0039] 3.9 g (0.02 mol) of methyl 2-methyl-3-nitrobenzoate was dissolved in 50 ml of chloroform, 5.3 g (0.04 mol) of NCS (chlorosuccinimide) was added, and the mixture was heated to reflux for 24 hours. After cooling, 100ml of water was added for liquid separation, the aqueous phase was extracted twice with 20ml of chloroform, combined with chlorofor...
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