Surface plasma resonance imaging analyzer

A surface plasmon and resonance imaging technology, which is used in the analysis of materials, material analysis by optical means, instruments, etc., to achieve the effect of simple installation, easy cleaning and maintenance, and easy replacement.

Active Publication Date: 2010-04-14
INST OF CHEM CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

However, this optical element requires the combination of two prisms, and the processing and assembly of the two prisms require high precision.

Method used

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Embodiment Construction

[0032] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0033] Such as Figure 6~7 As shown, the present invention includes an instrument base plate 19, a chassis shell (not shown in the figure), a rotating scanning mechanism 20, a fixed optical system 21, a sampling system 22 and an electrical control system 23. Wherein, the rotating scanning mechanism 20, the fixed optical system 21 and the sampling system 22 are all fixed on the surface of the instrument bottom plate 19 and arranged in the case shell, and the surface of the instrument bottom plate 19 is basically a horizontal plane. The electrical control system 23 is arranged in the case shell, and is electrically connected with the rotating scanning mechanism 20, the fixed optical system 21, and the sampling system 22 respectively, and can collect and control the images detected by the fixed optical system 21 and the images measured by the rotating sc...

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Abstract

The invention relates to a surface plasma resonance imaging analyzer, which comprises a rotary scanning mechanism, a fixed optical system, a light emission component, an optical receiving component, a feeding system, an electric control system and a principle computer. The rotary scanning mechanism comprises a rotary platform, a prism fixing frame, at least two right-angel prisms with different base angles, an incident angle reader, a positioning groove, at least one movable positioning pin, a brake element and a transmission mechanism. The fixed optical system comprises the light emission component and the optical receiving component, the light emission component and the optical receiving component are both arranged on the same side of a first normal of a right-angle face, and the light emission component comprises a light source and is equipped with a polarization element and a light collimating element on the light path of the light source. The optical receiving component comprises a detector and an imaging element group. The feeding system comprises a sample flowing tank and a sample driving mechanism. The principle computer acquires images, incident angles and temperature and electrically controls other equipment via the electric control system. The surface plasma resonance imaging analyzer guarantees system stability, realizes wide angle scanning of incident light, and can be used for working environments such as micro high-pass analysis of various samples including complex biological samples, drug testing or screening and the like.

Description

technical field [0001] The invention relates to a high-throughput biochemical analysis and measurement device, in particular to a surface plasmon resonance imaging analyzer. Background technique [0002] Surface Plasmon Resonance Imaging (SPRI) is a surface optical imaging technology developed from surface plasmon resonance spectroscopy, in which the surface is generally the interface between a solid and a liquid. Surface plasmon resonance imaging technology not only has the advantages of real-time and high sensitivity of surface plasmon resonance spectroscopy (Surface Plasmon Resonance, SPR), but also overcomes the shortcomings of a single channel of surface plasmon resonance spectroscopy. Signal changes across the membrane surface. Combining surface plasmon resonance imaging technology with biochip technology, the surface of the sensing membrane is modified with different probe molecular arrays to achieve high-throughput detection or screening of target objects in the sam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/41G01N21/01G02B7/18G02B1/00G02B1/04
Inventor 陈义张轶鸣许吉英
Owner INST OF CHEM CHINESE ACAD OF SCI
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