Hawthorn flavone extract pellets and preparation method thereof

A technology of hawthorn flavonoids and extracts, applied in food preparation, food science, drug combination, etc., can solve the problems of low bioavailability, irritation of gastric mucosa, long disintegration time, etc., and achieve high bioavailability and effectiveness Good, the effect of reducing the total dose

Inactive Publication Date: 2010-05-12
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the products of hawthorn flavonoid extract are well recognized by consumers. The commercially available products are basically ordinary tablets and capsules, but the above dosage forms have a long disintegration time and disintegrate at a certain point in the body. Some irritation to gastric mucosa, low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take the following ingredients for the recipe

[0033] Hawthorn Flavonoid Extract

35g

microcrystalline cellulose

62g

Hydroxypropylmethylcellulose

3g

[0034] Prepare pellet formulations as follows:

[0035] (1) Take the hawthorn flavonoid extract of the above-mentioned formula amount and add microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0036] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0037] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0039] Take the following ingredients for the recipe

[0040] Hawthorn Flavonoid Extract

50g

sucrose

48g

Polyvinylpyrrolidone

2g

[0041] Prepare pellet formulations as follows:

[0042] (1) Take the hawthorn flavonoid extract of the above-mentioned formula amount and add sucrose, pulverize it to a micronized level with a ball mill, and mix well;

[0043] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0044] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] Hawthorn Flavonoid Extract

70g

starch

26g

Polyvinylpyrrolidone

4g

[0048] Prepare pellet formulations as follows:

[0049] (1) Take the hawthorn flavonoid extract of the above-mentioned formula amount, add starch, pulverize to micronized level with a ball mill, and mix well;

[0050] (2) Polyvinylpyrrolidone is dissolved in an appropriate amount of water;

[0051] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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PUM

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Abstract

The invention provides a hawthorn flavone extract pellet preparation, which is prepared from hawthorn flavone extract and medicinal adjuvant and is characterized in that the medicinal adjuvant comprises excipient and adhesive, wherein the hawthorn flavone extract in the pellet preparation accounts for 10 to 90 percent by weight, the excipient accounts for 5 to 89 percent by weight, and the adhesive accounts for 1 to 5 percent by weight. The pellet preparation can be prepared into a slow-release or enteric-coated preparation as requested. The hawthorn flavone extract pellet preparation has high dissolution rate and high bioavailability; and the method of the invention is simple, convenient and easy to operate.

Description

Technical field: [0001] The invention relates to a micropill of natural food extract and a preparation method thereof, in particular to a micropill made of hawthorn flavone extract and a preparation method thereof. Background technique: [0002] Hawthorn, also known as "Shanlihong" and "Fairy Fruit", has high nutritional and medicinal value. Hawthorn contains a variety of vitamins, maslinic acid, tartaric acid, citric acid, malic acid, etc., and also contains flavonoids, lactones, sugars, proteins, fats, calcium, phosphorus, iron and other minerals. The pharmacological effects show that hawthorn has the effects of promoting digestion, strengthening the heart, lowering blood fat and blood pressure, antibacterial, scavenging free radicals, and diuresis. [0003] Hawthorn flavonoids are extracted from the leaves of Hawthorn, a plant of the Rosaceae Hawthorn genus. It is light brown or brown powder with special aroma, odorless and bitter taste. The main active ingredients are ...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61K9/16A61P9/10A23L1/30A61K127/00A23L33/105
Inventor魏洪君
OwnerJF PHARMALAND TECH DEV