Medicinal composition for treating diabetic nephropathy and preparation method thereof

Abstract

The invention relates to a medicinal composition for treating diabetic nephropathy and a preparation method thereof. The medicinal composition comprises the following raw materials in part by weight: 200 to 400 parts of radix astragali, 50 to 200 parts of rehmanniae praeparatum, 6 to 60 parts of sanchi, 20 to 100 parts of prepared rhubarb, 80 to 280 parts of euonymus alatus, 40 to 150 parts of fructus corni and 30 to 180 parts of bitter orange. The preparation method comprises the following steps: adding water into the raw materials for decoction for 1 to 4 times, adding water in an amount which is 8 to 12 times of raw materials each time; decocting the mixture for 0.5 to 2 hours, merging decoction, filtering the decoction, and decompressing and concentrating the decoction to prepare thick paste; and adding conventional auxiliary materials to prepare dosage forms such as pilula, pulvis, syrup, tablets, granules, capsules, plaster, mixtures, pills, suppositories, aerosols, ointment and the like. The medicinal composition has the effects of supplementing qi and nourishing yin, and promoting blood circulation by removing blood stasis, and has the excellent curative effect on diabetic nephropathy.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating diabetic nephropathy and a preparation method thereof. Background technique [0002] Diabetic nephropathy (DN) is a common microvascular complication of diabetes (diabetes mellitus, DM), the main cause of end-stage renal disease (ESRD), and the main cause of death from diabetes. primary reason. In my country, there are 40 million diabetic patients, and about 20-30% of them develop DN, which seriously endangers human health. In recent years, with the increasing prevalence of diabetes, the incidence of DN has also increased rapidly, and it has become one of the current research hotspots. Nodular or diffuse glomerulosclerosis caused by thickening of the glomerular basement membrane and progressive accumulation of extracellular matrix (ECM) in the mesangium is the main characteristic pathological change, so it ...

AI Technical Summary

Problems solved by technology

However, the pathogenesis of DN is still not fully understood,

[0003] Western medicine treatment of diabetic nephropathy mainly adopts hypoglycemic, lipid-lowering, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and other drugs for treatment. Although these therapeutic drugs have certain curative effects on DN and can delay the progression of the disease, Not very ideal, and there are many adverse drug reactions, and patients will inevitably develop chronic renal failure, leading to dialysis or death

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