Medicinal composition for treating diabetic nephropathy and preparation method thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of diabetic nephropathy and composition, applied in the field of pharmaceutical composition and its preparation, can solve problems such as death, unsatisfactory curative effect, and many adverse drug reactions
Active Publication Date: 2010-05-12
CHINA JAPAN FRIENDSHIP HOSPITAL
View PDF0 Cites 11 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, the pathogenesis of DN is still not fully understood,
[0003] Western medicine treatment of diabetic nephropathy mainly adopts hypoglycemic, lipid-lowering, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and other drugs for treatment. Although these therapeutic drugs have certain curative effects on DN and can delay the progression of the disease, Not very ideal, and there are many adverse drug reactions, and patients will inevitably develop chronic renal failure, leading to dialysis or death
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0165] 300g of astragalus, 120g of raw land, 30g of notoginseng, 60g of rhubarb, 150g of euonymus, 90g of cornus, 100g of citrus aurantium, add water and decoct 3 times, add 8 times the amount each time, decoct for 0.5 hours, combine the extracts, and decompress Concentrate to obtain a thick paste, dry, pulverize to obtain a dry powder, add 1.4 times the amount of dextrin, mix well, add an appropriate amount of 75% ethanol to granulate, dry to make granules, and take 8g orally once a day, twice a day.
Embodiment 2
[0167] Astragalus 260g, raw land 150g, Panax notoginseng 20g, rhubarb 80g, euonymus 120g, cornus 120g, citrus aurantium 60g, add 12 times the amount of water to decoct once, decoct for 1.5 hours, combine the extracts, concentrate under reduced pressure to get thick Paste, dry, pulverize to obtain dry powder, add appropriate amount of auxiliary materials, make tablets, take orally 3 times a day, 3-6 tablets each time.
Embodiment 3
[0169] Astragalus 350g, raw land 90g, Panax notoginseng 50g, rhubarb 40g, euonymus 180g, cornus 60g, citrus aurantium 140g, add water and decoct twice, add 10 times the amount each time, decoct for 1 hour, combine the extracts, reduce pressure Concentrate to obtain a thick paste, dry, pulverize to obtain dry powder, add appropriate auxiliary materials, make soft capsules, take 2-4 capsules each time, 3 times a day.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to a medicinal composition for treating diabetic nephropathy and a preparation method thereof. The medicinal composition comprises the following raw materials in part by weight: 200 to 400 parts of radix astragali, 50 to 200 parts of rehmanniae praeparatum, 6 to 60 parts of sanchi, 20 to 100 parts of prepared rhubarb, 80 to 280 parts of euonymus alatus, 40 to 150 parts of fructus corni and 30 to 180 parts of bitter orange. The preparation method comprises the following steps: adding water into the raw materials for decoction for 1 to 4 times, adding water in an amount which is 8 to 12 times of raw materials each time; decocting the mixture for 0.5 to 2 hours, merging decoction, filtering the decoction, and decompressing and concentrating the decoction to prepare thick paste; and adding conventional auxiliary materials to prepare dosage forms such as pilula, pulvis, syrup, tablets, granules, capsules, plaster, mixtures, pills, suppositories, aerosols, ointment and the like. The medicinal composition has the effects of supplementing qi and nourishing yin, and promoting blood circulation by removing blood stasis, and has the excellent curative effect on diabetic nephropathy.
Description
technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating diabetic nephropathy and a preparation method thereof. Background technique [0002] Diabetic nephropathy (DN) is a common microvascular complication of diabetes (diabetes mellitus, DM), the main cause of end-stage renal disease (ESRD), and the main cause of death from diabetes. primary reason. In my country, there are 40 million diabetic patients, and about 20-30% of them develop DN, which seriously endangers human health. In recent years, with the increasing prevalence of diabetes, the incidence of DN has also increased rapidly, and it has become one of the current research hotspots. Nodular or diffuse glomerulosclerosis caused by thickening of the glomerular basement membrane and progressive accumulation of extracellular matrix (ECM) in the mesangium is the main characteristic pathological change, so it ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more