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Application of composite of sweet wormwood herb and turtle shell in preparing antitumor medicine

A composition and anti-tumor technology, applied in the direction of anti-tumor drugs, drug combinations, antipyretics, etc., can solve problems such as the emergence of drugs

Inactive Publication Date: 2010-05-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large number of targets in the tumor microenvironment, no suitable drugs have been released so far.

Method used

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  • Application of composite of sweet wormwood herb and turtle shell in preparing antitumor medicine
  • Application of composite of sweet wormwood herb and turtle shell in preparing antitumor medicine
  • Application of composite of sweet wormwood herb and turtle shell in preparing antitumor medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Qinghao Biejia Tablets enhance the effect of cyclooxygenase 2 inhibitors on the chronic inflammatory response of S180 sarcoma

[0031] Inhibition effect

[0032] Drugs Qinghao Biejia Tablets (QHBJP), prepared according to the ministerial standard - traditional Chinese medicine standard (standard number WS3-B-1355). Meloxicam tablets (Meloxicam, batch number: 784187), Shanghai Boehringer Ingelheim Pharmaceutical Co., Ltd.

[0033] Tumor Strains and Animals Mouse S 180 Tumor strains, Shanghai Institute of Cell Biology, Chinese Academy of Sciences; ICR mice, Animal Experiment Center, Zhejiang Academy of Medical Sciences [Experimental animal license number: SX (Zhejiang) 2003-0001].

[0034] Reagents Immunohistochemistry Envision TM plus enhanced kit, Fuzhou Maixin Biotechnology Co., Ltd. COX-2 polyclonal antibody, Cayman Chemical Company. Goat anti-human Actin polyclonal antibody, Santa Cruz company. Enhanced chemiluminescence detection reagent, Santa Cru...

Embodiment 2

[0058] Example 2: Qinghao Biejia tablet regulates the hypoxic microenvironment of A549 human lung adenocarcinoma mediated by HIF-1α and its sensitization effect on cisplatin

[0059] Drugs Qinghao Biejia Tablets (QHBJP), prepared according to the ministerial standard - traditional Chinese medicine standard (standard number WS3-B-1355). Cisplatin for injection (CDDP, batch number: 709033100), Qilu Pharmaceutical Co., Ltd.

[0060] Tumor lines A549 lung adenocarcinoma cell line (Shanghai Institute of Cell Biology, Chinese Academy of Sciences), A549 cisplatin-resistant lung adenocarcinoma cell line (A549 / CDDP, Science Cell, USA).

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Abstract

The invention provides an application of a composite of sweet wormwood herb and turtle shell in preparing antitumor medicine. The composite comprises five traditional Chinese medicines, namely sweet wormwood herb, Colla Carapacis Trionycis, rehmanniae, rhizoma anemarrhenae and Tree peony bark, and preparation form thereof is solid. The composite provided by the invention has activity in antitumor chronic inflammation reaction, can be used for treating tumor inflammation reaction and angiogenesis process, and can be used as adjuvant therapy medicine and increase antitumor therapy of chemotherapeutics. The invention utilizes the theoretical background that tumors can generate various cells and cytokines by inducing under hypoxia microenvironment, researches and illustrates the miracle performance of traditional Chinese medicine, namely entering into collaterals for eliminating pathogens and leading pathogens out, provides important accordance for exploring new clinical value of famous and high-quality traditional Chinese medicine recipe, and points out new and important direction for developing traditional Chinese medicine theory.

Description

technical field [0001] The invention belongs to the application of traditional Chinese medicine prescriptions, and relates to the pharmaceutical application of Qinghao Biejia Fang in enhancing the antitumor curative effect of chemotherapy drugs. Background technique [0002] Qinghao Biejia prescription comes from Wu Jutong's "Tiaodian of Febrile Diseases" in the Qing Dynasty. The composition of the original prescription: Artemisia annua 6g, Turtle Shell 15g, Rehmannia glutinosa 12g, Anemarrhena 6g, Cortex Moutan 9g, which is a representative prescription for treating "yin deficiency and internal heat" in the late stage of febrile disease. [0003] For "yin deficiency and internal heat", the most in-depth study is "cancer fever". It is generally believed that the generation of cancer fever is related to the release of necrosis factors by tumors to stimulate the body to cause immune responses and the production of endogenous pyrogens by tumor cells themselves. The process of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P35/00A61P29/00A61K35/56A61K35/586
Inventor 周慧君张佳丽叶池蕾
Owner ZHEJIANG UNIV
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