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Medicament for treating gastric ulcer

A gastric ulcer and drug technology, applied in the field of drugs for the treatment of gastric ulcers, can solve problems such as no gastric ulcers

Active Publication Date: 2010-05-19
景德镇市农牧渔业科学研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, no one has used Pyramida or its extracts for the treatment of gastric ulcers

Method used

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  • Medicament for treating gastric ulcer
  • Medicament for treating gastric ulcer
  • Medicament for treating gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 The extraction of the crude extract of Pyracha chinensis

[0028] The crude matter of P. saponifera was extracted by biological enzymatic hydrolysis. The specific process is: raw material sampling analysis and testing before the production line → raw material acceptance → deep cleaning → enzymatic hydrolysis of combined bacteria → inactivation → dynamic temperature immersion extraction → low-temperature concentration → instant freezing → high-speed centrifugal sedimentation separation → spray drying → packaging inspection → Baihuahua Crude wood extract.

[0029] The specific extraction method is to crush the fresh material of P. chinensis. The biobroken product of P. candidum was obtained by enzymatic hydrolysis with combined bacteria, extracted by dynamic warm soaking method (temperature 85°C, time 120m, pH value 6.5±0.2), warm soaking extraction time was 16 hours, and the extract was obtained. First use alcohol extraction and water precipitation method to ...

Embodiment 2

[0033] Example 2 Preliminary Analysis Report on Chemical Components of P.

[0034] 1. Sample preparation

[0035] Finely weigh 1.06 mg of crude powder, dissolve in 1 mL of 50% methanol, and pass through a 0.45 μm microporous membrane to obtain the product.

[0036] 2. Chromatographic conditions

[0037] High-performance liquid chromatography: Agilent 1200 series high-performance liquid chromatography (Agilent Technologies, USA), including a diode array detector, a quaternary gradient pump, an online degasser, and an autosampler.

[0038] Column: YMC-Pack Pro C 18 (150mm×3.0mm ID, 5μm);

[0039] mobile phase:

[0040] A (methanol), B (0.1% formic acid H 2 O)

[0041] Gradient elution (0→35min, A: 10%→98%; 35min-40min, A: 98%→98%;);

[0042] Flow rate 0.3mL / min;

[0043] Column temperature: 40°C

[0044] UV scanning range: 200-400nm;

[0045] Detection wavelength: 200-400nm.

[0046] 3. Mass Spectrometry Conditions

[0047] 1. Mass spectrometer: Q TRAP TM Type quadr...

Embodiment 3

[0071] Example 3 The effect of the crude extract of P. chinensis on chronic gastric ulcer in rats induced by acetic acid

[0072] 1. Experimental materials

[0073] Tested product: Crude extract of P. chinensis, brown powdery solid, provided by Jiangxi Deyu Group. ① Weigh 10g + distilled water to suspend and dilute to 250ml. ② Take ①80ml and add distilled water to 160ml.

[0074] Positive control drug: pantoprazole sodium enteric-coated tablets, Shenyang Dongyu Pharmaceutical Co., Ltd., batch number: 080903, take 4 tablets (160mg) and add distilled water to dissolve and dilute to 160ml.

[0075] Animals: Wistar rats, male, weighing 180-220 g, provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences, certificate number, SCXK (Beijing) 2008-0004.

[0076] 2. Experimental method: 24 Wistar rats were fasted for 24 hours before the experiment. Open the abdominal cavity under ether anesthesia to expose the whole stomach, place a plastic tube with an i...

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PUM

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Abstract

The invention relates to a medicament prepared by using Chinese loropetalum herb as the main active component. Animal experiments and experiments in vitro prove that: the crude extract of the Chinese loropetalum herb can obviously reduce the gastric ulcer area of a rat, and has excellent safety without influencing the platelet aggregation function of the animals.

Description

Technical field: [0001] The invention relates to a medicine for treating gastric ulcer, in particular to a medicine prepared with loropetalum as the main active ingredient. Background technique: [0002] The main components of its extract are gallic acid, tannins, and flavonoids. Traditional Chinese medicine belongs to the category of healing internal and external wounds and astringent hemostatic drugs. It is clinically used for traumatic bleeding and internal organ bleeding and fire and water. scald. [0003] But no one has used Pyramida or its extracts for the treatment of gastric ulcer. Invention content: [0004] The purpose of the present invention is to develop a kind of medicine that is prepared by using P. loropetalum as raw material. [0005] The present invention finds that loropetalum or the extract of loropetalum has the effect of treating gastric ulcer, and can be used to prepare medicine for treating gastric ulcer. [0006] Said loropetalum includes flower...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/04A61K127/00A61K133/00A61K135/00
Inventor 刘浩元李晓滨曲淑娟
Owner 景德镇市农牧渔业科学研究所
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