Application of Phellinus pini polysaccharide extract in preparing medicament for preventing and treating tumor metastasis

A technology for extracting P. pine and polysaccharide, which can be used in anti-tumor drugs, drug combinations, medical raw materials derived from fungi, etc., and can solve the problems that have not been reported in the literature.

Inactive Publication Date: 2010-05-26
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, there is no literature report on the anti-tumor and anti-tumor effects of Phellinus pini polysaccharides extracted from Phellinus pini

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] (1) Water extraction: crush the fruiting body of Phylopore pine wood, pass through a 40-mesh sieve, take 1000g of powder, heat and extract twice with 1:20 distilled water at 90°C, each time for 2 hours, and combine the filtrates; concentration: (2) alcohol Sedimentation: Add 95% ethanol to the concentrated solution to precipitate the polysaccharide with a final concentration of 80% ethanol, and alcohol precipitation for 24 hours. The precipitate was obtained by suction filtration. (3) Drying: the precipitate was dried at 60° C. to obtain 20 g of polysaccharide powder from Ph. pinewood.

Embodiment 2

[0116] Get 10g of Phylopore pine polysaccharide powder, 50g of glucose water, make up to 1000ml. Preparation method: Take the polysaccharide powder of the prescribed amount, add part of water for injection at room temperature, stir well, add glucose, stir to dissolve, add water for injection to 1000ml, filter, pot, and sterilize to obtain 5ml of P. pine polysaccharide Injection.

Embodiment 3

[0118] Get 10g of Phylopore pine polysaccharide powder, 100g of mannitol, 90g of sodium chloride, and make up to 1000ml with water for injection. Preparation method: Take the prescription amount of Phylopore pine polysaccharide powder, dissolve it in an appropriate amount of water for injection at room temperature, stir to dissolve, add mannitol, stir to dissolve, add water for injection to 1000ml, and sterilize through No. 6 vertical melting filter Filtrate, fill the filtrate immediately under aseptic conditions, each tube is 5ml, seal it after freeze-drying, and obtain the freeze-dried powder injection of Phylopore pine polysaccharide.

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Abstract

The invention discloses application of Phellinus pini polysaccharide extract prepared from fruit body of Phellinus pini in preparing a medicament for preventing and treating tumor metastasis. The Phellinus pini polysaccharide extract prepared in the invention has obvious effects of activating polymorphonuclear leucocyte and improving capacity of killing tumor cells so as to inhibit the tumor metastasis and postoperative recurrence. Pharmacological tests prove that: the Phellinus pini polysaccharide extract has obvious treatment effect, is safe and effective and has no toxic or side effect. Meanwhile, the medicinal composition of the invention can be prepared into any anti-tumor preparation.

Description

technical field [0001] The invention belongs to the technical field of extracting traditional Chinese medicines, and in particular relates to a polysaccharide extract of Phalopore pinewood capable of inhibiting tumor metastasis and recurrence, a preparation method and an application thereof. Background technique [0002] As a kind of non-specific immune function enhancer, fungal polysaccharides have been widely used in the prevention and treatment of autoimmune diseases and malignant tumors in clinical practice, such as lentinan, ganoderma polysaccharide, versicolor polysaccharide, brazilian mushroom polysaccharide and other anti-tumor effects It has been extensively validated clinically. Phellinus (Polyraceae, fungus in the genus Phellinus) as a Chinese medicinal material was first recorded in "Compendium of Materia Medica" in my country. Its fruiting body is used as medicine, with a slightly bitter taste, which can benefit the five internal organs, soften and harden, detox...

Claims

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Application Information

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IPC IPC(8): A61K36/06A61P35/04C08B37/00
Inventor 张艳军马琳张密霞庄朋伟李怡文王阳徐甜甜
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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