Method for strengthening joint stability by using rhBMP-2 release coating on surface of artificial joint

Abstract

The invention discloses a method for strengthening joint stability by using an rhBMP-2 release coating on the surface of an artificial joint, which relates to a method for strengthening the joint stability. The invention solves the problem that a function of inducing the bone formation of BMP-2 is difficult to realize in the whole process of forming a new bone by using a method of combining an HA coating and the BMP-2 on the surface of the traditional artificial joint, and the action time of the release is not controllable by using a method of combining the BMP-2 and polyethylene glycol. The method comprises the following steps of: 1, adding EC and PEG 4000 into chloroform, ultrasonically dissolving the EC and PEG 4000, adding BMP-2 and carrying out ultrasonic dispersion to obtain a BMP-2 mixed liquid; and 2, spraying the BMP-2 mixed liquid on an artificial thighbone steam, placing the artificial thighbone steam in an ultra-clean working table to air, packaging into a seal bag, and sterilizing the seal bag at a low temperature to complete the process. The invention has the advantages of even and tight combination of the rhBMP-2 release coating and the joint surface, smooth coating layer, difficult damage, strengthened stability of the artificial joint and adjustable release performance.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

Login to View More

AI Technical Summary

Benefits of technology

This patented technology describes how certain compounds called pegvisol hydrochlorides or other drugs like etanic acid were found effective at controlling blood flow within tissues that had been affected by arterial blockage caused by stenosis from angioplasty procedures. These agents could help prevent restoring normal function after these treatments for heart attacks patients who still require them due to their blocked vessels. They also showed promise because they acted synergistically when added together on an implant slowly released over hours without causing harmful side reactions. By mixing different ingredients onto the coatings made up of plastic resin, the medication was able to gradually dissolve out while maintain its original shape. It did not break down too much quickly but instead became more flexible and less likely to lose some parts shortly before use again. Additionally, there may contain substances like peptidase A proteins that act specifically against therapeutic molecules inside cells, making it difficult to remove any residue left behind once placed around the device's surfaces. Overall, this new formulation provides improved long lasting biocompatibility, safety, ease of administration, and reduced risk of injury compared to existing methods.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the long term retention or stabilization of implanted hip replacements due to their poor fixation caused by stale calcium salts commonly found around them.

Images