Human epididymis expression sperm binding protein HEL-172 as well as encoding gene and application thereof

A technology of HEL-172 and binding protein, applied in the direction of anti-animal/human immunoglobulin, application, gene therapy, etc., can solve the problem of little known protein function and achieve the effect of less side effects
CN101724062AInactive Publication Date: 2010-06-09李建远
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
李建远
Publication Date
2010-06-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to biotechnology and medical field and discloses a new human epididymis specific expression sperm binding protein HEL-172 and preparation and application thereof. The invention discloses an amino acid sequence of the HEL-172 protein and provides a recombination expression vector carrying a DNA sequence for encoding the protein. The invention further discloses a method for preparing the protein and detecting the biological function of the HEL-172 protein. The protein is positioned at the back region of the head of a mature sperm, has expression in epididymis and spermary, heart, liver, spleen, kidney and stomach. A band of about 34 KD is detected in the epididymis by using Western blot. The HEL-172 protein can be used as a target protein for the research and development of immunity acyeterion as well as clinical diagnosis and treatment of male infertility. The relevant gene or protein detecting method based on the protein HEL-172 can be widely applied to the reproductive medicine research field.
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Description

technical field

[0001] The invention belongs to the field of biotechnology and medicine. Specifically, the present invention relates to a new human epididymis expressing sperm-binding protein HEL-172 and its coding gene and application Background technique

[0002] The development of human beings in this century is facing two serious problems: on the one hand, the global population is rapidly expanding and is expected to reach 9 billion in 2050; on the other hand, according to the World Health Organization survey, about 15% of couples are infertile The problem is that the incidence of infertility in developed countries has soared in the past 10 years, and it can be as high as 30% in developed countries in Europe, of which male factors account for about half. The World Health Organization predicts that with the increase of environmental pollution and sexually transmitted diseases and other pathogenic factors, infertility will become the third major disease after tumors and c...

Claims

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