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Chinese medicinal composition and detection method for Chinese medicinal composition preparation

A detection method and composition technology, applied in the direction of drug combination, pharmaceutical formula, non-central analgesics, etc., can solve the problems of imperfect drug quality standards and low specificity

Active Publication Date: 2010-06-23
TONG REN TANG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, there are many traditional Chinese medicine products for the treatment of children's colds on the market. Although there are various varieties, the quality standards of the medicines are not perfect. Therefore, it is urgent to improve the quality standards of drugs, improve quality controllability, and ensure drug safety

Method used

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  • Chinese medicinal composition and detection method for Chinese medicinal composition preparation
  • Chinese medicinal composition and detection method for Chinese medicinal composition preparation
  • Chinese medicinal composition and detection method for Chinese medicinal composition preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0169] Embodiment 1: the detection method of oral liquid preparation of Chinese medicine composition of the present invention

[0170] The raw material medicine is composed of:

[0171] Patchouli 85g Chrysanthemum 85g Forsythia 85g

[0172] Daqingye 141g Banlangen 85g Rehmannia glutinosa 85g

[0173] Digupi 85g Baiwei 85g Mint 56g

[0174] Gypsum 141g

[0175] Take patchouli, peppermint, and chrysanthemum from the above-mentioned raw materials to extract volatile oil, and collect the distilled aqueous solution in another device; decoct medicinal residues and other seven flavors such as forsythia in water for 2 times (gypsum is first decocted for 1 hour), the first time for 2 hours, For the second 1 hour, combine the decoction, filter, combine the filtrate with the above aqueous solution, concentrate to a clear paste with a relative density of 1.20 (50°C), let it cool, add ethanol to make the alcohol content 65%, refrigerate for 48 hours, filter After passing, the filtrate ...

Embodiment 2

[0188] Embodiment 2: the detection method of Chinese medicine composition tablet of the present invention

[0189] The raw material medicine is composed of:

[0190] Patchouli 77g Chrysanthemum 90g Forsythia 94g

[0191] Daqingye 138g Banlangen 76g Rehmannia glutinosa 93g

[0192] Digupi 94g Baiwei 78g Mint 46g

[0193] Gypsum 149g

[0194] Take the above raw materials, add conventional auxiliary materials, and make tablets according to conventional processes;

[0195] Identification:

[0196] A. Identification of Patchouli

[0197] Take 1 / 2 of the daily dose of the tablet, grind it, add ether to the suspension state, shake and extract 3 times, combine the ether solution, put it on a water bath and concentrate it to 2ml, and use it as the test solution; Medicinal material 0.4g, add ethanol 10ml to extract, as reference medicinal material solution; Test according to thin-layer chromatography (Appendix VIB of Chinese Pharmacopoeia 2005 edition, one appendix VIB), suck each...

Embodiment 3

[0205] Determination method: precision draws each 0.8 μ l of reference substance solution and need testing solution, injects gas chromatograph, measures, and obtains promptly; 15 h 26 O) shall not be less than 170μg. Embodiment 3: the detection method of Chinese medicine composition pill of the present invention

[0206] The raw material medicine is composed of:

[0207] Patchouli 94g Chrysanthemum 77g Forsythia 76g

[0208] Daqingye 148g, Banlangen 93g, Rehmannia glutinosa 78g

[0209] Digupi 76g Baiwei 95g Mint 64g

[0210] Gypsum 135g

[0211] Take the above raw materials, add conventional auxiliary materials, and make pills according to conventional processes;

[0212] Identification:

[0213] A. Identification of Patchouli

[0214] Take 1 times the amount of the daily preparation of the pill, grind it, add ether to the suspended state, shake and extract 3 times, combine the ether solution, put it on a water bath and concentrate it to 1ml, and use it as the test so...

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Abstract

The invention relates to a detection method for a Chinese medicinal composition preparation, in particular to the detection method for a preparation for treating infantile common cold. The method carries out identification on thin-layer chromatographies of cablin potchouli herb and mint, and by repeated experimental observation, the chromatography of the tested preparation shows the spots with the same color and has suitable Rf value, good repeatability and no interference in the blank on a position corresponding to the chromatography of the reference medicaments. And the method also experiments on the method for measuring the content of patchouli alcohol in cablin potchouli herb, carries out optimization on experiment conditions, such as the temperature programming, the flow rate of carrier gas, the extracting time and the like, and repeatedly experiments on linear relation, precision, repeatability, stability and recovery ratio, and the result is excellent. The invention improves the controllability of the medicament quality and is beneficial for the quality control in the industrial production.

Description

technical field [0001] The invention relates to a detection method of a traditional Chinese medicine composition preparation, in particular to a detection method of a preparation for treating colds in children. Background technique [0002] At present, there are many traditional Chinese medicine products for the treatment of children's colds on the market. Although there are various varieties, the quality standards of the medicines are not perfect. Therefore, it is urgent to improve the quality standards of drugs, improve quality controllability, and ensure drug safety. Contents of the invention [0003] The purpose of the invention is to disclose a detection method of a traditional Chinese medicine composition preparation. [0004] The object of the invention is achieved through the following technical solutions: [0005] The detection method of the present invention includes one or more of the following identification and content determination: [0006] Identification...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P11/00A61P29/00A61P31/00G01N30/02G01N30/90A61K33/06
Inventor 郑杰赵红英刘莹迟玉明解素花
Owner TONG REN TANG TECH CO LTD
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