Method for separating red cells from blood sample and application

A technology for red blood cells and blood samples, applied in the field of detection devices, can solve the problems of loss of sensitivity, ineffective detection, expensive and other problems, and achieve the effect of prolonging the service life and prolonging the use time.

Active Publication Date: 2010-06-23
ABON BIOPHARM HANGZHOU
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Many of these techniques for separating RBCs from plasma are expensive, complex, and can result in incomplete separation of RBCs
Especially for those whole blood samples that have been placed for a long time and have clotted, the existing technology cannot separate them well
In particular, in a chromatography immunoassay device, this clotted s

Method used

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  • Method for separating red cells from blood sample and application
  • Method for separating red cells from blood sample and application
  • Method for separating red cells from blood sample and application

Examples

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Embodiment Construction

[0013] The structures involved in the present invention or the technical terms used are further described below.

[0014] detection

[0015] To detect means to assay or test for the presence of a substance or material such as, but not limited to, a chemical substance, an organic compound, an inorganic compound, a metabolic product, a drug or a drug metabolite, an organic tissue or a metabolite of an organic tissue, a nucleic acid, protein or polymer. Additionally, detection means the amount of a substance or material tested. Further, assay also means immunoassay, chemical assay, enzyme assay, etc.

[0016] fibrin and receptors for fibrin

[0017] Fibrinogen is the earliest coagulation factor discovered. It is an elongated spheroid, which is a dimer formed by three pairs of polypeptide chains (a pair of α chains, a pair of β chains, and a pair of γ chains) connected by disulfide bonds, and its molecular weight is about 340,000 Daltons . After being synthesized in the live...

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Abstract

The invention relates to a device and a method for separating red cells from a blood sample and a device and a method for detecting analyzed substances in the blood sample. The method for separating red cells from the blood sample comprises the following steps: making the blood sample contact receptors of fibrin in a combined blood sample; and separating out the receptors of the fibrin from the blood sample. The device for detecting the analyzed substances in the blood sample comprises a carrier which comprises a detection area, and the device is characterized in that the upstream of the detection area comprises the receptors of the fibrin in the combined blood sample. The red cells in the blood sample can be effectively separated by using the devices and the methods so as to reduce the obstruction effect of the red cells on liquid flow and the interference of the red cells on a response background. The methods and the devices do not cause adverse effects on the detection results.

Description

technical field [0001] The present invention relates to a device and method for separating red blood cells from whole blood samples, and more specifically to a detection device, which uses the method and device for separating red blood cells by separating fibrin from whole blood to reduce the interference of red blood cells on the test results . Background technique [0002] Modern clinical diagnostic methods are usually performed on blood samples. Unfortunately, red blood cells interfere with many diagnostic tests. This requires the red blood cells to be separated from the blood sample first, and then the sample is further tested or assayed. On the other hand, in chromatographic assays, especially in immunoassays, erythrocytes may block fluid flow, which is essential for reactions to take place on such assays. For this reason and others, many tests are performed with plasma or serum, which requires separation of plasma or serum from whole blood. [0003] There are many ...

Claims

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Application Information

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IPC IPC(8): G01N1/34G01N33/53G01N33/558
Inventor 刘毅刘杰马天涯吴银飞高飞
Owner ABON BIOPHARM HANGZHOU
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