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Pharmaceutical composition of cefcapene pivoxil hydrochloride granules and preparation method thereof

A technology of cefcapine hydrochloride and a composition, which is applied in the directions of drug combinations, pharmaceutical formulations, antibacterial drugs, etc., can solve the problems of masking of bitter taste, bitter taste of cefcapine pivoxil, no antibacterial effect of Pseudomonas aeruginosa, and the like, Achieve the effect of mature technology and simple operation

Inactive Publication Date: 2011-11-16
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The third-generation oral cephalosporins have broad-spectrum antibacterial activity and have strong bactericidal effect on both G+ and G- bacteria, but have no antibacterial effect on Enterococcus, methicillin-resistant Staphylococcus and Pseudomonas aeruginosa
[0011] In addition, the taste of cefcapene axetil is so bitter that it cannot be masked with traditional sweeteners or flavorings, which can cause serious problems when administered orally to children

Method used

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  • Pharmaceutical composition of cefcapene pivoxil hydrochloride granules and preparation method thereof
  • Pharmaceutical composition of cefcapene pivoxil hydrochloride granules and preparation method thereof
  • Pharmaceutical composition of cefcapene pivoxil hydrochloride granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] The composition of the prescription is (based on 1000 bags)

[0088] Composition 1 Cefcapene Proxil Hydrochloride 50g

[0089] Carboxymethyl Starch Sodium 25g

[0090] Microcrystalline Cellulose 150g

[0091] Aqueous solution of sodium carboxymethylcellulose

[0092] Composition 2 Xylitol 200g

[0093] 200g pregelatinized starch

[0094] Aspartame 8g

[0095] 5% povidone 50% ethanol solution appropriate amount

[0096] Composition 3 Magnesium Stearate 2g

[0097] Lemon essence 0.4g

Embodiment 2

[0099] The composition of the prescription is (based on 1000 bags)

[0100] Composition 1 Cefcapene Proxil Hydrochloride 50g

[0101] Croscarmellose Sodium 50g

[0102] Sorbitol 150g

[0103] Aqueous solution of sodium carboxymethylcellulose

[0104] Composition 2 Xylitol 150g

[0105] Microcrystalline Cellulose 200g

[0106] Aspartame 10g

[0107] 5% povidone 70% ethanol solution appropriate amount

[0108] Composition 3 Magnesium Stearate 1g

[0109] Orange essence 0.2g

Embodiment 3

[0111] The composition of the prescription is (based on 1000 bags)

[0112] Composition 1 Cefcapene Proxil Hydrochloride 50g

[0113] Croscarmellose Sodium 50g

[0114] Mannitol 150g

[0115] 10% ethyl cellulose 80% ethanol solution appropriate amount

[0116] Composition 2 Xylitol 150g

[0117] Microcrystalline Cellulose 200g

[0118] Aspartame 6g

[0119] 5% povidone 70% ethanol solution appropriate amount

[0120] Composition 3 Starch 1g

[0121] Cherry essence 0.3g

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Abstract

The invention discloses a pharmaceutical composition of cefcapene pivoxil hydrochloride granules, which utilizes high-efficiency antibacterial action of cefcapene pivoxil and adopts oral preparation drug administration, thus having antibiosis function rapidly. The pharmaceutical composition has the expected performance characteristic in the aspect of covering the bitter taste of cefcapene pivoxilhydrochloride, and has high bioavailability and stability of the cefcapene pivoxil hydrochloride, thus being beneficial to orally taking the cefcapene pivoxil hydrochloride. The invention also relates to a preparation method of the pharmaceutical composition of the cefcapene pivoxil hydrochloride granules.

Description

technical field [0001] The invention relates to oral cefcapene pivoxil hydrochloride granules and a preparation method thereof. The granules can well mask the bitter taste of cefcapene pixil hydrochloride and exhibit high bioavailability of cefcapene pixil hydrochloride. Background technique [0002] Cefcapene Proxil Hydrochloride, its chemical name is (6R,7R)-3-(carbamoyloxy)methyl-7-[(2Z)-2-(2-aminothiazol-4-yl)-1-oxygen Generation-2-pentenyl]amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2.2-dimethyl-1-oxo Propoxy) methyl ester hydrochloride monohydrate, its structural formula is as follows: [0003] [0004] Indications: superficial skin infection, deep skin infection, lymphatic vessel and lymphadenitis, chronic pyoderma. Pharyngitis, tonsillitis (including peritonsillar inflammation, peritonsillar abscess), acute bronchitis, pneumonia. Cystitis, pyelonephritis. Otitis media, sinusitis. scarlet fever. [0005] In recent years, antimicrobial d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/546A61P31/04A61P17/02A61P11/00A61P11/02A61P11/04A61P13/10A61P13/12A61P27/16
Inventor 严洁刘建邦黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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