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Silver-loaded antibacterial artificial joint and preparation method thereof

An artificial joint, silver-loaded antibacterial technology, which is applied in the field of replacing silver and achieves the effects of high sterilization efficiency, promotion of deposition growth, and resistance to drugs

Inactive Publication Date: 2010-07-07
江苏广达医材集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Technical problem: The purpose of this invention is to address the above-mentioned shortcomings of artificial joint materials, and propose an artificial joint with a slow-release function of trace element silver, which can significantly improve the ability of the artificial joint surface to induce osteogenesis at the initial stage of implantation, and its preparation method

Method used

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  • Silver-loaded antibacterial artificial joint and preparation method thereof
  • Silver-loaded antibacterial artificial joint and preparation method thereof
  • Silver-loaded antibacterial artificial joint and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) First choose Ti6Al4V alloy to process the artificial joint;

[0026] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. The time is 6 hours, and a sodium titanate bioactive coating with a microporous structure is obtained on the surface of the artificial joint.

[0027] (3) Silver doping treatment by immersion method: immerse the surface hydrothermally treated artificial joint at a concentration of 5×10 -2 mol / L AgNO 3 In solution, AgNO with an operating temperature of 60°C 3 The solution was kept constant using a water bath method. Stir with a magnetic stirrer, take out after soaking for 2 to 12 hours, ultrasonically clean with distilled water, and dry at room temper...

Embodiment 2

[0031] (1) First choose Ti6Al4V alloy to process the artificial joint;

[0032] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. The time is 6 hours.

[0033] (3) Silver doping treatment by immersion method: immerse the surface hydrothermally treated artificial joint at a concentration of 2×10 -1 mol / L AgNO 3 In solution, AgNO with an operating temperature of 60°C 3The solution was kept constant using a water bath method. Stir with a magnetic stirrer, take out after soaking for 2 to 12 hours, ultrasonically clean with distilled water, and dry at room temperature.

[0034] (4) Centrifugal load treatment of BMP: fix the artificial joint with silver-doped sodium titanate bioacti...

Embodiment 3

[0037] (1) First choose Ti6Al4V alloy to process the artificial joint;

[0038] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 150 degrees Celsius. The time is 72 hours, and a sodium titanate bioactive coating with microporous structure is obtained on the surface of the artificial joint, and its SEM photos and XRD spectra are shown in figure 1 with figure 2 .

[0039] (3) Silver doping treatment by immersion method: immerse the surface hydrothermally treated artificial joint at a concentration of 5×10 -2 mol / L AgNO 3 In solution, AgNO with an operating temperature of 60°C 3 The solution was kept constant using a water bath method. Stir with a magnetic stirrer, take out after soaking for 2 to ...

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Abstract

The invention relates to a silver-loaded antibacterial artificial joint and a preparation method thereof. The silver-loaded antibacterial artificial joint consists of a pure titanium or titanium alloy artificial joint substrate and a micropore sodium titanate bioactivity layer loaded with microelement silver and bone morphogenetic protein (BMP). The sodium titanate bioactivity layer with a micropore structure is combined with the metal substrate surface and is formed by mutually alternately stacking the sodium titanate micropore sodium structures generated by the hydro-thermal reaction between the titanium or titanium alloy substrate surface and sodium hydroxide solution. The silver element and sodium carry out cation exchange to dope into a coating. The BMP is compounded in the micropore structures under the action of the centrifugal force and the capillary. The preparation method comprises the following steps: firstly selecting pure titanium or titanium alloy to process the artificial joint; then adopting the alkaline hydrothermal synthesis technology obtain a sodium titanate layer with the micropore structures on the surface of the titanium artificial joint; doping trace silver in the micropore sodium titanate layer by solution impregnation iron exchange; and finally adopting the centrifugal load technology to load the bone morphogenetic protein in the silver-doped micropore sodium titanate layer.

Description

technical field [0001] The invention relates to a silver-loaded antibacterial artificial joint and a preparation method thereof, in particular to a method of processing a base made of pure titanium or a titanium alloy, and adopting a lye hydrothermal synthesis technique to obtain a microporous sodium titanate bioactive coating, which is passed through a solution The invention relates to an artificial joint impregnated with ion exchange mixed with silver and loaded with bone morphogenetic protein using centrifugal loading technology and a preparation method thereof, belonging to the technical field of artificial joint materials. Background technique [0002] At present, the number of cases of artificial joint implanted into the human body can reach 1.2 million cases per year, and it is one of the implant materials with the largest demand in orthopedics at home and abroad. The commonly used artificial joints are metal materials. Because they are biologically inert materials, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/06A61L27/54A61L27/56C01G23/00
Inventor 储成林饶席浦跃朴
Owner 江苏广达医材集团有限公司
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